Surface Wettability of a Natural Rubber Composite under Stretching: A Model to Predict Cell Survival

Author(s):Show less -

do Nascimento, Rodney Marcelo ^{[1, 2, 3]} ; Schmitt, Jean-Francois ^[3] ; Sarig, Udi ^{[4, 5]} ; Figueiredo Soares Rodrigues, Joao Elias ^{[6, 7]} ; Pecharroman, Carlos ^[6] ; Ramos, Ana Paula ^[8] ; Ciancaglini, Pietro ^[8] ; Faita, Fabricio Luiz ^[9] ; Rahouadj, Rachid ^[3] ; Hernandes, Antonio Carlos ^[2] ; Bechtold, Ivan Helmuth ^[1]

Affiliation

^[1] Univ Fed Santa Catarina, Dept Fis, BR-88040900 Florianopolis, SC - Brazil

^[2] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13566590 Sao Carlos - Brazil

^[3] Univ Lorraine Nancy Metz, Lab Etud Microstruct Mecan Mat & Vivant, LEM3 UMR CNRS 7239, F-57070 Nancy, Meurthe Moselle - France

^[4] Biotechnol & Food Engn Technion Israel Inst Techn, IL-32000 Haifa - Israel

^[5] Guangdong Technion Israel Inst Technol, Shantou 515063 - Peoples R China

^[6] CSIC, Inst Ciencia Mat Madrid, E-28049 Madrid - Spain

^[7] ESRF, European Synchrotron Radiat Facil, F-38000 Grenoble - France

^[8] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040900 Ribeirao Preto - Brazil

^[9] Univ Fed Rio Grande do Sul, Inst Fis UFRGS, BR-91501970 Porto Alegre, RS - Brazil

• Document type: Journal article
• Source: Langmuir; v. 37, n. 15, p. 4639-4646, APR 20 2021.
• Web of Science Citations: 0

Abstract

We report the stress-strain effect of a stretchable natural rubber (NR)-calcium phosphate composite on the surface wettability (SW) using an innovative approach coupling a uniaxial tensile micromachine, goniometer, and microscope. In situ contact angle measurements in real time were performed during mechanical tension. Our results show that SW is guided by the stress-strain relationship with two different characteristics, depending on the static or dynamic experiments. The results evidenced the limits of the classical theory of wetting. Furthermore, based on the mechanically tunable SW of the system associated with the cytocompatibility of the NR composite, we have modeled such a system for application as a cell support. From the experimental surface energy value, our proposed 3D modeling numerical simulation predicted a window of opportunities for cell-NR survival under mechanical stimuli. The presented data and the thermodynamics-based theoretical approach enable not only accurate correlation of SW with mechanical properties of the NR composite but also provide huge potential for future cell supportability in view of tissue engineering. (AU)

• FAPESP's process: 13/21970-8 - Development of biomaterial from the incorporation of calcium phosphates in latex structures to order application as controlled release device
• Grantee: Rodney Marcelo do Nascimento
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/03842-3 - Study of the Guided Tissue Regeneration (GTR) through experimental analysis in temporo-mandibular joint's disc and NR-CaP occlusive membranes
• Grantee: Rodney Marcelo do Nascimento
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor