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Development of biomaterial from the incorporation of calcium phosphates in latex structures to order application as controlled release device

Grant number: 13/21970-8
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): February 01, 2014
Effective date (End): January 31, 2019
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Antônio Carlos Hernandes
Grantee:Rodney Marcelo Do Nascimento
Home Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated scholarship(s):17/03842-3 - Study of the guided tissue regeneration (GTR) through experimental analysis in temporo-mandibular joint's disc and NR-CaP occlusive membranes, BE.EP.PD


This project about the development of a biomaterial obtained by incorporation of particles of calcium phosphates Ca/P with different structures and morphologies in polymeric structure latex processed. The forms in which the particles are aggregated to polymeric structure, as the interactions between the particles and the proteins present in natural latex will be investigated. It is expected that the biomaterial developed can be applied in device to release osteogenic potential particles gradually in biological environment. The initial stages of tissue regeneration will be investigated using simulated body fluid. Besides the gradual releasing system, the material will be developed to act as a mechanical barrier, like a dressing applicable in the dental field. This theme is present and contributes directly to improving the quality of life of the society. Furthermore, the generation of knowledge, products and processes in this area is crucial to the development of science and technology and is housed in a strategic area of the country. The Center of Technology for Hybrid Materials, of the São Carlos Institute of Physics, USP, and the Center for Development of Functional Materials (CEPID/FAPESP, Project number 2013/07296-2) will support the project.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DO NASCIMENTO, RODNEY MARCELO; RAMOS, ANA PAULA; CIANCAGLINI, PIETRO; HERNANDES, ANTONIO CARLOS. Blood droplets on functionalized surfaces: Chemical, roughness and superhydrophobic effects. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 574, p. 188-196, AUG 5 2019. Web of Science Citations: 0.
DO NASCIMENTO, RODNEY MARCELO; DE PAULA, AMAURI JARDIM; OLIVEIRA, NAIARA CIPRIANO; ALVES, ANA CECILIA; LIMA DE OLIVEIRA AQUINO, YASMINE MARIA; SOUZA FILHO, ANTONIO GOMES; FIGUEIREDO SOARES RODRIGUES, JOAO ELIAS; HERNANDES, ANTONIO CARLOS. Towards the production of natural rubber-calcium phosphate hybrid for applications as bioactive coatings. Materials Science & Engineering C-Materials for Biological Applications, v. 94, p. 417-425, JAN 1 2019. Web of Science Citations: 0.
DO NASCIMENTO, RODNEY MARCELO; RAMOS, STELLA M. M.; BECHTOLD, IVAN HELMUTH; HERNANDES, ANTONIO CARLOS. Wettability Study on Natural Rubber Surfaces for Applications as Biomembranes. ACS BIOMATERIALS SCIENCE & ENGINEERING, v. 4, n. 8, p. 2784-2793, AUG 2018. Web of Science Citations: 0.

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