Development of biomaterial from the incorporation of calcium phosphates in latex structures to order application as controlled release device

• Grant number: 13/21970-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: February 01, 2014
• End date: January 31, 2019
• Field of knowledge: Health Sciences - Dentistry - Dental Materials
• Principal Investigator: Antônio Carlos Hernandes
• Grantee: Rodney Marcelo do Nascimento
• Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated scholarship(s): 17/03842-3 - Study of the Guided Tissue Regeneration (GTR) through experimental analysis in temporo-mandibular joint's disc and NR-CaP occlusive membranes, BE.EP.PD

Abstract

This project about the development of a biomaterial obtained by incorporation of particles of calcium phosphates Ca/P with different structures and morphologies in polymeric structure latex processed. The forms in which the particles are aggregated to polymeric structure, as the interactions between the particles and the proteins present in natural latex will be investigated. It is expected that the biomaterial developed can be applied in device to release osteogenic potential particles gradually in biological environment. The initial stages of tissue regeneration will be investigated using simulated body fluid. Besides the gradual releasing system, the material will be developed to act as a mechanical barrier, like a dressing applicable in the dental field. This theme is present and contributes directly to improving the quality of life of the society. Furthermore, the generation of knowledge, products and processes in this area is crucial to the development of science and technology and is housed in a strategic area of the country. The Center of Technology for Hybrid Materials, of the São Carlos Institute of Physics, USP, and the Center for Development of Functional Materials (CEPID/FAPESP, Project number 2013/07296-2) will support the project.

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DO NASCIMENTO, RODNEY MARCELO; SARIG, UDI; DO CRUZ, NILSON CRISTINO; DE CARVALHO, VANESSA RAFAELA; EYSSARTIER, CAMILLE; SIAD, LARBI; GANGHOFFER, JEAN-FRANCOIS; HERNANDES, ANTONIO CARLOS; RAHOUADJ, RACHID. Optimized-Surface Wettability: A New Experimental 3D Modeling Approach Predicting Favorable Biomaterial-Cell Interactions. ADVANCED THEORY AND SIMULATIONS, v. 2, n. 7, JUL 2019. (17/03842-3, 13/21970-8)

DO NASCIMENTO, RODNEY MARCELO; COTTIN-BIZONNE, CECILE; PIRAT, CHRISTOPHE; RAMOS, STELLA M. M.. Water Drop Evaporation on Mushroom-like Superhydrophobic Surfaces: Temperature Effects. Langmuir, v. 32, n. 8, p. 2005-2009, MAR 1 2016. (13/21970-8)

DO NASCIMENTO, RODNEY MARCELO; DE PAULA, AMAURI JARDIM; OLIVEIRA, NAIARA CIPRIANO; ALVES, ANA CECILIA; LIMA DE OLIVEIRA AQUINO, YASMINE MARIA; SOUZA FILHO, ANTONIO GOMES; FIGUEIREDO SOARES RODRIGUES, JOAO ELIAS; HERNANDES, ANTONIO CARLOS. Towards the production of natural rubber-calcium phosphate hybrid for applications as bioactive coatings. Materials Science & Engineering C-Materials for Biological Applications, v. 94, p. 417-425, JAN 1 2019. (13/21970-8)

DO NASCIMENTO, RODNEY MARCELO; DE CARVALHO, VANESSA RAFAELA; GOVONE, JOSE SILVIO; HERNANDES, ANTONIO CARLOS; DA CRUZ, NILSON CRISTINO. Effects of negatively and positively charged Ti metal surfaces on ceramic coating adhesion and cell response. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 28, n. 2, FEB 2017. (13/21970-8)

DO NASCIMENTO, RODNEY MARCELO; SCHMITT, JEAN-FRANCOIS; SARIG, UDI; FIGUEIREDO SOARES RODRIGUES, JOAO ELIAS; PECHARROMAN, CARLOS; RAMOS, ANA PAULA; CIANCAGLINI, PIETRO; FAITA, FABRICIO LUIZ; RAHOUADJ, RACHID; HERNANDES, ANTONIO CARLOS; et al. Surface Wettability of a Natural Rubber Composite under Stretching: A Model to Predict Cell Survival. Langmuir, v. 37, n. 15, p. 4639-4646, APR 20 2021. (13/21970-8, 17/03842-3)

DO NASCIMENTO, RODNEY MARCELO; RAMOS, ANA PAULA; CIANCAGLINI, PIETRO; HERNANDES, ANTONIO CARLOS. Blood droplets on functionalized surfaces: Chemical, roughness and superhydrophobic effects. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 574, p. 188-196, AUG 5 2019. (13/21970-8)

DO NASCIMENTO, RODNEY MARCELO; RAMOS, STELLA M. M.; BECHTOLD, IVAN HELMUTH; HERNANDES, ANTONIO CARLOS. Wettability Study on Natural Rubber Surfaces for Applications as Biomembranes. ACS BIOMATERIALS SCIENCE & ENGINEERING, v. 4, n. 8, p. 2784-2793, AUG 2018. (13/21970-8)

DO NASCIMENTO, RODNEY MARCELO; BALDIT, ADRIEN; KOKANYAN, NINEL; TAPPERT, LARA KRISTIN; LIPINSKI, PAUL; HERNANDES, ANTONIO CARLOS; RAHOUADJ, RACHID. Mechanical-chemical coupling in Temporomandibular Joint disc. MATERIALIA, v. 9, MAR 2020. (17/03842-3, 13/21970-8)