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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

MicroRNA-mediated extracellular matrix remodeling in squamous cell carcinoma of the oral cavity

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Author(s):
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Menderico Junior, Gilberto Mendes [1] ; Theodoro, Therese Rachell [2] ; Pasini, Fatima Solange [3] ; de Menezes Ishikawa, Marina [4] ; Santos, Nayara Stephanie Sousa [5] ; de Mello, Evandro Sobroza [6] ; da Silva Pinhal, Maria Aparecida [2] ; Moyses, Raquel Ajub [7] ; Kulcsar, Marco Aurelio Vamondes [8] ; Dedivitis, Rogerio Aparecido [9] ; Cernea, Claudio Roberto [9] ; Kowalski, Luiz Paulo [9] ; de Matos, Leandro Luongo [10]
Total Authors: 13
Affiliation:
[1] Univ Sao Paulo, Head & Neck Surg Dept, Anesthesiol Surg Sci & Perioperat Med, Med Sch, Sao Paulo - Brazil
[2] Fac Med ABC, Biochem Dept, Santo Andre, SP - Brazil
[3] Univ Sao Paulo HCFMUSP, Ctr Invest Translac Oncol CTO, Inst Canc Estado Sao Paulo ICESP, Hosp Clin, Fac Med, Sao Paulo - Brazil
[4] Fac Israelita Ciencias Saude Albert Einstei, Nursery Sch, Sao Paulo - Brazil
[5] Univ Sao Paulo, Med Sch, Sao Paulo - Brazil
[6] Univ Sao Paulo, Inst Canc Estado Sao Paulo ICESP, Lab Invest Med 14 LIM14, Pathol Dept, Med Sch, Sao Paulo - Brazil
[7] Univ Sao Paulo, Head & Neck Surg Dept, Lab Invest Med 28 LIM28, Med Sch, Sao Paulo - Brazil
[8] Univ Sao Paulo, Head & Neck Surg Dept, Inst Canc Estado Sao Paulo ICESP, Med Sch, Sao Paulo - Brazil
[9] Univ Sao Paulo, Head & Neck Surg Dept, Med Sch, Sao Paulo - Brazil
[10] Univ Sao Paulo, Head & Neck Surg Dept, Inst Canc Estado Sao Paulo, Lab Invest Med 28 LIM 28, Med Sch, Sao Paulo - Brazil
Total Affiliations: 10
Document type: Journal article
Source: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 43, n. 8, p. 2364-2376, AUG 2021.
Web of Science Citations: 0
Abstract

Background We evaluated microRNAs and extracellular matrix component profiles in squamous cell carcinoma of the oral cavity (OSCC) in comparison to healthy mucosa. Methods Retrospective study investigating 64 microRNAs related to oncogenic process and to constituents of the extracellular matrix. We also performed immunohistochemical assays for molecules involved in the same biological processes. Results High expression of miR-21-5p (p < 0.001) and miR-106-5p (p < 0.001) and low expression of miR-320a (p = 0.001) and miR-222-3p (p = 0.001) were predictors of malignancy. Individually, miR-21-5p exhibited the best statistical performance (area under the curve = 0.972; 95% confidence interval: 0.911-1.000) in the differentiation between tumor tissue and healthy mucosa. Moreover, tumor sample showed increased expression of MMP-2, MMP-9, alpha-laminin, and beta-laminin in tumor-related fibroblasts and lower continuity of type IV collagen in the basement membrane. Conclusion The present study demonstrates the biological effects of microRNAs on the carcinogenesis of OSCC as well as the intense modification of the tumor microenvironment. (AU)

FAPESP's process: 16/01740-6 - Proteoglycans profile and micro-RNA expression associated to tumor invasion and prognosis in oral cavity squamous cell carcinoma
Grantee:Leandro Luongo de Matos
Support type: Regular Research Grants