| Full text | |
| Author(s): Show less - |
Souza, Lucas Lacerda de
[1, 2]
;
Caceres, Cinthia Veronica Bardalez Lopez de
[1]
;
Vargas, Pablo Agustin
[1]
;
Lopes, Marcio Ajudarte
[1]
;
Santos-Silva, Alan Roger
[1]
;
Silva, Wagner Gomes da
[3]
;
Prado-Ribeiro, Ana Carolina
[1, 3]
;
Brandao, Thais Bianca
[3]
;
Pereira, Juliana
[4]
;
Mesquita, Ricardo Alves
[5]
;
Pontes, Flavia Sirotheau Correa
[2]
;
Gonzalez-Arriagada, Wilfredo Alejandro
[6]
;
Pedraza, Ricardo Martinez
[7]
;
Andrade, Bruno Augusto Benevenuto de
[8]
;
Romanach, Mario Jose
[8]
;
Soares, Ciro Dantas
[9]
;
Carvalho, Maria Goretti Freire de
[9]
;
Pires, Fabio Ramoa
[10]
;
Carlos, Roman
[11]
;
Fonseca, Felipe Paiva
[1, 5]
;
Pontes, Helder Antonio Rebelo
[1, 2]
;
de Almeida, Oslei Paes
[1]
Total Authors: 22
|
| Affiliation: Show less - | [1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba - Brazil
[2] Fed Univ Para, Joao Barros Barreto Univ Hosp, Serv Oral Pathol, Belem, Para - Brazil
[3] Inst Canc Estado Sao Paulo, Dent Oncol Serv, Sao Paulo - Brazil
[4] Univ Sao Paulo, Hosp Clin, Dept Hematol, Fac Med, Sao Paulo - Brazil
[5] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, Av Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG - Brazil
[6] Univ Andes, Fac Odontol, Patol Oral & Maxilofacial, Santiago - Chile
[7] Univ Autonoma Nuevo Leon, Sch Dent, Dept Adv Gen Dent Master, Monterrey - Mexico
[8] Univ Fed Rio de Janeiro, Sch Dent, Dept Oral Diag & Pathol, Rio De Janeiro - Brazil
[9] Private Pathol Lab, Natal, RN - Brazil
[10] Univ Estado Rio De Janeiro, Oral Pathol, Rio De Janeiro - Brazil
[11] Ctr Clin Cabeza & Cuello, Guatemala City - Guatemala
Total Affiliations: 11
|
| Document type: | Journal article |
| Source: | JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 50, n. 6, p. 613-621, JUL 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Background Plasma cell neoplasms are characterized by the proliferation of a single clone of plasma cells with production of a monoclonal immunoglobulin. They can manifest as a single lesion (plasmacytoma) or as multiple lesions (multiple myeloma). Methods Paraffin-embedded tissue blocks of patients microscopically diagnosed with plasma cell neoplasms in the jaws were retrieved from five pathology files. Data including clinical, radiographic, microscopic and immunohistochemical findings, treatment employed and follow-up status were retrieved from the pathology reports. Results Fifty-two cases were retrieved (mean age: 59.4 years) without sex predilection. The mandible was the most affected site (67.3%), usually associated with pain and/or paresthesia (53.8%). Lesions in other bones besides the jaws were reported for 24 patients (46.2%). Radiographically, tumours usually presented as poorly defined osteolytic lesions with unilocular or multilocular images, while microscopy revealed diffuse proliferation of neoplastic plasma cells with nuclear displacement and abundant eosinophilic cytoplasm. Two cases were classified as anaplastic, and amyloid deposits were found in two other cases. Immunohistochemistry was positive for plasma cell markers and negative for CD20 and CD3, and monoclonality for kappa light chain predominated. The overall survival rate after 5 years of follow-up was 26.6%. Conclusion Plasma cell neoplasms are aggressive tumours with a poor prognosis and involvement of the jaws may be the first complaint of the patient. Thus, oral pathologists, head and neck surgeons and dentists should be aware of their clinical, radiographic and microscopic manifestations. (AU) | |
| FAPESP's process: | 17/14880-3 - Clinicopathological and immunohistochemical analysis of follicular lymphoid hyperplasias and lymphomas of the oral cavity |
| Grantee: | Oslei Paes de Almeida |
| Support Opportunities: | Regular Research Grants |