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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Green and Red Brazilian Propolis: Antimicrobial Potential and Anti-Virulence against ATCC and Clinically Isolated Multidrug-Resistant Bacteria

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Author(s):
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Silva, Thayna de Souza [1] ; Silva, Julia M. B. [1] ; Braun, Glaucia H. [1] ; Mejia, Jennyfer A. A. [2] ; Ccapatinta, Gari V. C. [2] ; Conceicao Santos, Mario Ferreira [1] ; Tanimoto, Matheus H. [2] ; Bastos, Jairo K. [2] ; Parreira, Renato L. T. [1] ; Orenha, Renato P. [1] ; Borges, Alexandre [3] ; Berretta, Andresa A. [4] ; Veneziani, Rodrigo C. S. [1] ; Martins, Carlos H. G. [5] ; Ambrosio, Sergio R. [1]
Total Authors: 15
Affiliation:
[1] Univ Franca, Av Dr Armando de Salles Oliveira 201, Franca, SP - Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Av Cafe S-N, Ribeirao Preto - Brazil
[3] Univ Ctr Santa Fe do Sul, Fac Med, Av Mangara 477, Campus 2, Santa Fe Do Sul - Brazil
[4] Apis Flora Indl Coml Ltda, Lab Pesquisa Desenvolvimento & Inovacao, Ribeirao Preto - Brazil
[5] Univ Fed Uberlandia, Dept Microbiol, Av Para 1720, Bloco 2B, Sala 221, Uberlandia, MG - Brazil
Total Affiliations: 5
Document type: Journal article
Source: CHEMISTRY & BIODIVERSITY; v. 18, n. 8 AUG 2021.
Web of Science Citations: 1
Abstract

Brazilian green and red propolis stand out as commercial products for different medical applications. In this article, we report the antimicrobial activities of the hydroalcoholic extracts of green (EGP) and red (ERP) propolis, as well as guttiferone E plus xanthochymol (8) and oblongifolin B (9) from red propolis, against multidrug-resistant bacteria (MDRB). We undertook the minimal inhibitory (MIC) and bactericidal (MBC) concentrations, inhibition of biofilm formation (MICB50), catalase, coagulase, DNase, lipase, and hemolysin assays, along with molecular docking simulations. ERP was more effective by displaying MIC and MBC values <100 mu g mL(-1). Compounds 8 and 9 displayed the lowest MIC values (0.98 to 31.25 mu g mL(-1)) against all tested Gram-positive MDRB. They also inhibited the biofilm formation of S. aureus (ATCC 43300 and clinical isolate) and S. epidermidis (ATCC 14990 and clinical isolate), with MICB50 values between 1.56 and 6.25 mu g mL(-1). The molecular docking results indicated that 8 and 9 might interact with the catalase's amino acids. Compounds 8 and 9 have great antimicrobial potential. (AU)

FAPESP's process: 18/13700-4 - HSCCC method development for the isolation and identification of red propolis constituents
Grantee:Gari Vidal Ccana Ccapatinta
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector
Grantee:Jairo Kenupp Bastos
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 19/01697-1 - Phytochemical study and cytotoxic evaluation of the hexanic fraction and isolated compounds from red propolis produced by Apis mellifera L.
Grantee:Matheus Hikaru Tanimoto
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/05080-6 - Multi-user equipment approved in grant 2017/04138-8 for high pressure semipreparative chromatographic system model LC-20AR
Grantee:Sergio Ricardo Ambrosio
Support Opportunities: Multi-user Equipment Program