The Chemistry and Biological Applications of 3H-Pyrrolo[2,3-c]quinolines and Marinoquinolines

Author(s)

do Espirito Santo, Rafael Dias ^[1] ; Capitao, Rebeca Monique ^[1] ; Barbosa, Patricia Santos ^[1] ; Simao dos Santos, Eric Francisco ^[1] ; Duarte Correia, Carlos Roque ^[1]

Affiliation

^[1] Univ Estadual Campinas, Dept Organ Chem, Chem Inst, UNICAMP, BR-13083970 Campinas, SP - Brazil

• Document type: Review article
• Source: ASIAN JOURNAL OF ORGANIC CHEMISTRY; v. 10, n. 8, p. 1938-1957, AUG 2021.
• Web of Science Citations: 0

Abstract

The heterocyclic 3H-pyrrolo{[}2,3-c]quinoline system and its closely related natural products, the marinoquinolines, have been attracting considerable attention in recent years in view of its interesting chemistry and diverse biological activities. Known since 1924, only in 2006 were the 3H-pyrrolo{[}2,3-c]quinolines associated with the first marinoquinolines isolated from natural sources. Their architecture and biological activities such as antiplasmodial, anti-proliferative, anti-bacterial, antifungal, phosphodiesterase and AChE inhibitors, and as ion-sensing have stimulated the development of new strategies to obtain the natural marinoquinolines and new 3H-pyrrolo{[}2,3-c]quinoline derivatives. This review details the recent synthesis and biological evaluation of natural and unnatural marinoquinolines and its 3H-pyrrolo{[}2,3-c]quinoline core. (AU)

• FAPESP's process: 14/25770-6 - New frontiers in cross-coupling reactions promoted by palladium: combining enantioselective catalysis, C-H activations, new materials and in flux reactions aiming at high efficiency and sustainability in synthetic processes
• Grantee: Carlos Roque Duarte Correia
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/11316-0 - Synthesis and evaluation of new marinoquinolines with potential antimalarial activity
• Grantee: Rafael Dias Do Espírito Santo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 18/03143-0 - DEVELOPMENT OF NEW MARINOQUINOLINES AS ANTIMALARIAL AGENTS: DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION
• Grantee: Patricia Santos Barbosa
• Support Opportunities: Scholarships in Brazil - Doctorate