A simple coronary blood flow model to study the collateral flow index

Author(s)

Blanco, Pablo J. ^{[1, 2]} ; Bulant, Carlos A. ^{[3, 4, 2]} ; Ares, Gonzalo D. ^[5] ; Lemos, Pedro A. ^{[6, 2]} ; Feijoo, Raul A. ^{[1, 2]}

Affiliation

^[1] Lab Nacl Comp Cient, Av Getulio Vargas 333, BR-25651075 Petropolis, RJ - Brazil

^[2] Natl Inst Sci & Technol Med Assisted Sci Comp, INCT MACC, Petropolis, RJ - Brazil

^[3] Consejo Nacl Invest Cient & Tecn, Natl Sci & Tech Res Council, Tandil - Argentina

^[4] Natl Univ Ctr, Tandil - Argentina

^[5] Natl Univ Mar Del Plata, Mar Del Plata - Argentina

^[6] Hosp Israelita Albert Einstein, Sao Paulo - Brazil

• Document type: Journal article
• Source: BIOMECHANICS AND MODELING IN MECHANOBIOLOGY; v. 20, n. 4, p. 1365-1382, AUG 2021.
• Web of Science Citations: 0

Abstract

In this work, we present a novel modeling framework to investigate the effects of collateral circulation into the coronary blood flow physiology. A prototypical model of the coronary tree, integrated with the concept of Collateral Flow Index (CFI), is employed to gain insight about the role of model parameters associated with the collateral circuitry, which results in physically-realizable solutions for specific CFI data. Then, we discuss the mathematical feasibility of pressure-derived CFI, anatomical implications and practical considerations involving the estimation of model parameters in collateral connections. A sensitivity analysis is carried out, and the investigation of the impact of the collateral circulation on FFR values is also addressed. (AU)

• FAPESP's process: 14/50889-7 - National Institute of Science and Technology Medicine Assisted by Scientific Computing (INCT-MACC)
• Grantee: José Eduardo Krieger
• Support Opportunities: Research Projects - Thematic Grants