| Full text | |
| Author(s): |
Ruat, Julia
[1, 2]
;
Heinz, Daniel E.
[3, 4]
;
Binder, Florian P.
[5, 2]
;
Stark, Tibor
[6, 7]
;
Neuner, Robert
[3]
;
Hartmann, Alice
[3]
;
Kaplick, Paul M.
[3]
;
Chen, Alon
[1, 8]
;
Czisch, Michael
[6]
;
Wotjak, Carsten T.
[3, 4, 9]
Total Authors: 10
|
| Affiliation: | [1] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, D-80804 Munich - Germany
[2] Int Max Planck Res Sch Translat Psychiat IMPRS TP, D-80804 Munich - Germany
[3] Max Planck Inst Psychiat, Res Grp Neuronal Plast, Kraepelinstr 2-10, D-80804 Munich - Germany
[4] Max Planck Sch Cognit, D-04103 Leipzig - Germany
[5] Max Planck Inst Psychiat, Dept Translat Res Psychiat, D-80804 Munich - Germany
[6] Max Planck Inst Psychiat, Sci Core Unit Neuroimaging, D-80804 Munich - Germany
[7] Masaryk Univ, Fac Med, Dept Pharmacol, Brno 62500 - Czech Republic
[8] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot - Israel
[9] Boehringer Ingelheim Pharma GmbH & Co KG, Cent Nervous Syst Dis Res CNSDR, D-88397 Biberach - Germany
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 111, DEC 20 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Post-traumatic stress disorder (PTSD) is a chronic disease caused by traumatic incidents. Numerous studies have revealed grey matter volume differences in affected individuals. The nature of the disease renders it difficult to distinguish between a priori versus a posteriori changes. To overcome this difficulty, we studied the consequences of a traumatic event on brain morphology in mice before and 4 weeks after exposure to brief foot shocks (or sham treatment), and correlated morphology with symptoms of hyperarousal. In the latter context, we assessed hyperarousal upon confrontation with acoustic, visual, or composite (acoustic/visual/tactile) threats and integrated the individual readouts into a single Hyperarousal Score using logistic regression analysis. MRI scans with subsequent whole-brain deformation-based morphometry (DBM) analysis revealed a volume decrease of the dorsal hippocampus and an increase of the reticular nucleus in shocked mice when compared to non-shocked controls. Using the Hyperarousal Score as regressor for the post-exposure MRI measurement, we observed negative correlations with several brain structures including the dorsal hippocampus. If the development of changes with respect to the basal MRI was considered, reduction in globus pallidus volume reflected hyperarousal severity. Our findings demonstrate that a brief traumatic incident can cause volume changes in defined brain structures and suggest the globus pallidus as an important hub for the control of fear responses to threatening stimuli of different sensory modalities. (AU) | |
| FAPESP's process: | 18/17387-9 - Evaluation of the endocannabinoid signaling and cannabidiol effects on immunological parameters in a psychopathological mouse model of trait anxiety |
| Grantee: | Alice Hartmann dos Santos |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |