| Full text | |
| Author(s): Show less - |
da Silva, Roberta Fernanda
[1]
;
Lacchini, Riccardo
[2]
;
Pinheiro, Lucas Cezar
[2]
;
Ferezin, Leticia Perticarrara
[3]
;
Tanus-Santos, Jose Eduardo
[4]
;
Luizon, Marcelo Rizzatti
[5]
;
Dionisio, Thiago Jose
[6]
;
Santos, Carlos Ferreira
[6]
;
Reia, Thais Amanda
[1]
;
Jacomini, Andre Mourao
[1]
;
Moreno, Ana Maria Guilmo
[1]
;
Zago, Anderson Saranz
[1, 7]
Total Authors: 12
|
| Affiliation: | [1] Sao Paulo State Univ Unesp, Sch Sci, Postgrad Program Movement Sci, Dept Phys Educ, Bauru, SP - Brazil
[2] Univ Sao Paulo, Dept Psychiat Nursing & Human Sci, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Genet, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao, Dept Pharmacol, Ribeirao Preto, SP - Brazil
[5] Univ Minas Gerais Fed, Inst Biol Sci, Dept Genet Ecol & Evolut, Belo Horizonte, MG - Brazil
[6] Univ Sao Paulo, Bauru Sch Dent, Dept Pharmacol, Bauru, SP - Brazil
[7] Sao Paulo State Univ Unesp, Sch Sci, Ctr Noncommun Dis Aging & Exercise Stud CEDEE, Dept Phys Educ, Bauru, SP - Brazil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | CLINICAL AND EXPERIMENTAL HYPERTENSION; v. 43, n. 7, p. 661-670, OCT 3 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Introduction:Variations in blood pressure (BP) are, in part, genetically determined and some polymorphisms of renin-angiotensin- aldosterone system (RAAS) and synthase of endothelial nitric oxide (eNOS) have been related to hypertension (HT). Conversely, physical exercise is considered a non-pharmacological tool for HT control, treatment, and prevention. Objective: The purpose of this study is to investigate the relationship between eNOS and RAAS polymorphisms, their epistatic interaction, and the respective humoral factors in the BP control in normotensive/pre-hypertension and hypertensive older adults and how this relationship can be modulated by training status (TS) level. Methods:A total of 155 older adults (66.94 +/- 6.83 years old) performed the following evaluations: AAHPERD battery test to determine the general functional fitness index (GFFI), systolic and diastolic blood pressure (SBP and DBP), blood collection for DNA extraction, analysis of eNOS gene polymorphisms rs2070744; rs61722009 and rs1799983 and RAAS polymorphisms rs699; rs1799752 and rs5186, and quantification of ACE activity (Fluorimetric Assay) and nitrite concentration (Chemiluminescence Method). Results and Conclusion:Good TS level appears to exert greater influence on SBP for G2 and G3 (G1: 125.79 +/- 14.03/ G2: 119.91 +/- 11.72(/)G3: 119.71 +/- 10.85) and on NO2 for G3 (G1: 0.42 +/- 0.25/ G2: 0.54 +/- 0.45/ G3: 0.71 +/- 0.52). No associations were observed between eNOS and RAAS polymorphisms, but the epistasis was identified between eNOS polymorphism, rs2070744, and RAAS polymorphism, rs699, revealing a statistically significant interaction (p = .0235) with training score of 0.63, a training test accuracy of 0.61 and a cross-validation consistency of 10/10. This result suggests an increased risk of hypertension. (AU) | |
| FAPESP's process: | 15/24847-8 - Comparative analysis of the mechanisms involved in the regulation of blood pressure during acute physical exercise in adults and elderly, hypertensive and normotensive and individuals with different level of training status |
| Grantee: | Anderson Saranz Zago |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/03965-2 - Role of the renin-angiotensin system in different oral inflammatory models: an experimental interdisciplinary and clinical approach |
| Grantee: | Carlos Ferreira dos Santos |
| Support Opportunities: | Research Projects - Thematic Grants |