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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Human Fallopian Tube - Derived Mesenchymal Stem Cells Inhibit Experimental Autoimmune Encephalomyelitis by Suppressing Th1/Th17 Activation and Migration to Central Nervous System

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de Freitas, Carla Longo [1, 2] ; Polonio, Carolina Manganeli [1, 2] ; Brandao, Wesley Nogueira [1, 2] ; Rossato, Cristiano [1, 2] ; Zanluqui, Nagela Ghabdan [3, 1, 2] ; de Oliveira, Lilian Gomes [1, 2] ; de Oliveira, Marilia Garcia [1, 2] ; Evangelista, Lucila Pires [2, 4] ; Halpern, Silvio [2, 5] ; Maluf, Mariangela [2, 6] ; Czresnia, Carlos Eduardo [2, 4] ; Perin, Paulo [2, 6] ; de Almeida, Danilo Candido [2, 7] ; Schatzmman Peron, Jean Pierre [3, 1, 2]
Total Authors: 14
[1] Univ Sao Paulo, Neuroimmune Interact Lab, Dept Immunol, Av Prof Lineu Prestes, 1730 Lab 232, Cidade Univ, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sci Platform Pasteur USP, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Immunopathol & Allergy Post Grad Program, Sao Paulo - Brazil
[4] Celula Mater Clin, Reprod Med Div, Sao Paulo - Brazil
[5] Halpern Clin, Reprod Med Div, Sao Paulo - Brazil
[6] CEERH Clin, Reprod Med Div, Sao Paulo - Brazil
[7] Fed Univ Sao Paulo UNIFESP, Nephrol Div, Sao Paulo - Brazil
Total Affiliations: 7
Document type: Journal article
Web of Science Citations: 0

Mesenchymal stem cells comprise a natural reservoir of undifferentiated cells within adult tissues. Given their self-renewal, multipotency, regenerative potential and immunomodulatory properties, MSCs have been reported as a promising cell therapy for the treatment of different diseases, including neurodegenerative and autoimmune diseases. In this study, we investigated the immunomodulatory properties of human tubal mesenchymal stem cells (htMSCs) using the EAE model. htMSCs were able to suppress dendritic cells activation downregulating antigen presentation-related molecules, such as MHCII, CD80 and CD86, while impairing IFN-gamma and IL-17 and increasing IL-10 and IL-4 secretion. It further correlated with milder disease scores when compared to the control group due to fewer leukocytes infiltrating the CNS, specially Th1 and Th17 lymphocytes, associated with increased IL-10 secreting Tr1 cells. Conversely, microglia were less activated and infiltrating mononuclear cells secreted higher levels of IL-4 and IL-10 and expressed reduced chemokine receptors as CCR4, CCR6 and CCR8. qPCR of the spinal cords revealed upregulation of indoleamine-2,3-dioxygenase (IDO) and brain derived neurotrophic factor (BDNF). Taken together, here evidenced the potential of htMSCs as an alternative for the treatment of inflammatory, autoimmune or neurodegenerative diseases. (AU)

FAPESP's process: 20/06145-4 - Immunopathogenesis of COVID-19 in experimental models and nasal vaccine anti-SARS-CoV-2
Grantee:Jean Pierre Schatzmann Peron
Support type: Regular Research Grants
FAPESP's process: 16/07371-2 - Characterization of the role of T CD8+ lymphocytes in Zika virus infection
Grantee:Nagela Ghabdan Zanluqui
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/10242-5 - The role of ionotropic glutamate receptor NMDA in innate and adaptive immune cells from intestinal mucosa in murine experimental model
Grantee:Marília Garcia de Oliveira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/11828-0 - Evaluation of the microRNAs role in the immunopathogenesis of microcephaly caused by Zika virus in experimental models
Grantee:Carolina Manganeli Polonio
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/22504-1 - TAM receptors and their ligands Gas6 and Pros1 on the ZIKV Congenital Syndrome in Experimental Models
Grantee:Jean Pierre Schatzmann Peron
Support type: Regular Research Grants
FAPESP's process: 17/26170-0 - Neuroimmunology in experimental models of Autoimmune Encephalomyelitis and Congenital Zika Syndrome: physiopathogenesis, susceptibility, cellular therapy, vaccination
Grantee:Jean Pierre Schatzmann Peron
Support type: Research Projects - Thematic Grants