Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Extracellular miRNAs in redox signaling: Health, disease and potential therapies

Full text
Ruiz, Gabriel Palermo [1] ; Camara, Henrique [1] ; Fazolini, Narayana P. B. [1] ; Mori, Marcelo A. [1, 2, 3]
Total Authors: 4
[1] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Expt Med Res Cluster EMRC, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Free Radical Biology and Medicine; v. 173, p. 170-187, SEP 2021.
Web of Science Citations: 2

Extracellular microRNAs (miRNAs) have emerged as important mediators of cell-to-cell communication and intertissue crosstalk. MiRNAs are produced by virtually all types of eukaryotic cells and can be selectively packaged and released to the extracellular medium, where they may reach distal cells to regulate gene expression cell non-autonomously. By doing so, miRNAs participate in integrative physiology. Oxidative stress affects miRNA expression, while miRNAs control redox signaling. Disruption in miRNA expression, processing or release to the extracellular compartment are associated with aging and a number of chronic diseases, such as obesity, type 2 diabetes, neurodegenerative diseases and cancer, all of them being conditions related to oxidative stress. Here we discuss the interplay between redox balance and miRNA function and secretion as a determinant of health and disease states, reviewing the findings that support this notion and highlighting novel and yet understudied venues of research in the field. (AU)

FAPESP's process: 17/01184-9 - CAMeLEOm: cross-species analysis of metabolic, lifespan effects and omics of dietary restriction mimetics
Grantee:Marcelo Alves da Silva Mori
Support type: Research Projects - Thematic Grants
FAPESP's process: 17/23920-9 - Varredura e caracterização de moléculas circulantes que afetam o gasto energético
Grantee:Raissa Guimarães Ludwig
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/01339-2 - Uncovering mechanisms of longevity mediated by mobile RNAs
Grantee:Henrique Camara
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/07975-8 - Exploring the role of adipose tissue-derived circulating miRNAs in the beneficial effects of exercise training
Grantee:Marcelo Alves da Silva Mori
Support type: Regular Research Grants
FAPESP's process: 18/21635-8 - Study of the role of miR-203-3p in adipose tissue metabolism and in the pathogenesis of metabolic diseases in mice
Grantee:Gabriel Palermo Ruiz
Support type: Scholarships in Brazil - Doctorate (Direct)