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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control

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Valli, Marilia [1] ; Atanazio, Leticia Cristina Vieira [2] ; Monteiro, Gustavo Claro [3] ; Coelho, Roberta Ramos [3] ; Demarque, Daniel Pecoraro [3] ; Andricopulo, Adriano Defini [1] ; Espindola, Laila Salmen [3] ; Bolzani, Vanderlan da Silva [2]
Total Authors: 8
[1] Univ Sao Paulo, Inst Phys Sao Carlos, Ctr Res & Innovat Biodivers & Drug Discovery CIBF, Lab Med & Computat Chem LQMC, Sao Carlos - Brazil
[2] Sao Paulo State Univ UNESP, Dept Organ Chem, Nuclei Bioassays Biosynth & Ecophysiol Nat Prod N, Araraquara, SP - Brazil
[3] Univ Brasilia, Lab Farmacognosia, Campus Univ Darcy Ribeiro, BR-70910900 Brasilia, DF - Brazil
Total Affiliations: 3
Document type: Review article
Source: Planta Medica; v. 87, n. 01/02, p. 6-23, FEB 2021.
Web of Science Citations: 0

Natural products are a valuable source of biologically active compounds and continue to play an important role in modern drug discovery due to their great structural diversity and unique biological properties. Brazilian biodiversity is one of the most extensive in the world and could be an effective source of new chemical entities for drug discovery. Mosquitoes are vectors for the transmission of dengue, Zika, chikungunya, yellow fever, and many other diseases of public health importance. These diseases have a major impact on tropical and subtropical countries, and their incidence has increased dramatically in recent decades, reaching billions of people at risk worldwide. The prevention of these diseases is mainly through vector control, which is becoming more difficult because of the emergence of resistant mosquito populations to the chemical insecticides. Strategies to provide efficient and safe vector control are needed, and secondary metabolites from plant species from the Brazilian biodiversity, especially Cerrado, that are biologically active for mosquito control are herein highlighted. Also, this is a literature revision of targets as insights to promote advances in the task of developing active compounds for vector control. In view of the expansion and occurrence of arboviruses diseases worldwide, scientific reviews on bioactive natural products are important to provide molecular models for vector control and contribute with effective measures to reduce their incidence. (AU)

FAPESP's process: 14/50926-0 - INCT 2014: biodiversity and natural products
Grantee:Vanderlan da Silva Bolzani
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 19/05967-3 - Understanding the biological function of Natural Products' scaffolds from Databases for the design of active compounds for the treatment of infectious diseases
Grantee:Marilia Valli
Support type: Scholarships in Brazil - Post-Doctorate