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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ass spectrometry-based metabolomics in microbiome investigation

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Author(s):
Bauermeister, Anelize [1, 2] ; Mannochio-Russo, Helena [3, 2] ; Costa-Lotufo, Leticia V. [1] ; Jarmusch, Alan K. [2] ; Dorrestein, Pieter C. [2, 4, 5]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
[2] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, Collaborat Mass Spectrometry Innovat Ctr, San Diego, CA 92103 - USA
[3] Sao Paulo State Univ, Inst Chem, Dept Biochem & Organ Chem, Araraquara, SP - Brazil
[4] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 - USA
[5] Univ Calif San Diego, Ctr Microbiome Innovat, San Diego, CA 92103 - USA
Total Affiliations: 5
Document type: Review article
Source: NATURE REVIEWS MICROBIOLOGY; v. 20, n. 3 SEP 2021.
Web of Science Citations: 3
Abstract

Mass spectrometry-based metabolomics is one of the key technologies to detect and identify the small molecules produced by the human microbiota and to understand the functional role of these microbial metabolites. In this Review, Dorrestein and colleagues review common forms of untargeted mass spectrometry and the types of data that can be obtained in the context of microbiome analysis. Microbiotas are a malleable part of ecosystems, including the human ecosystem. Microorganisms affect not only the chemistry of their specific niche, such as the human gut, but also the chemistry of distant environments, such as other parts of the body. Mass spectrometry-based metabolomics is one of the key technologies to detect and identify the small molecules produced by the human microbiota, and to understand the functional role of these microbial metabolites. This Review provides a foundational introduction to common forms of untargeted mass spectrometry and the types of data that can be obtained in the context of microbiome analysis. Data analysis remains an obstacle; therefore, the emphasis is placed on data analysis approaches and integrative analysis, including the integration of microbiome sequencing data. (AU)

FAPESP's process: 15/17177-6 - Integrative approach on the sustainable prospection of marine natural products: from diversity to anticancer compounds
Grantee:Leticia Veras Costa Lotufo
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 18/24865-4 - New approaches in metabolomics: 3D Molecular cartography of ascidians based on LC-MS/MS data
Grantee:Anelize Bauermeister
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 18/07098-0 - Effects of marine pharmaceuticals in zebrafish and ZFL cell line - emphasis
Grantee:Leticia Veras Costa Lotufo
Support Opportunities: Regular Research Grants