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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

wo-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular flui

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Goncalves, Rafael Simoes [1] ; Candia Scaffa, Polliana Mendes [2] ; Shinohara, Mirela Sanae [1] ; Marao de Andrade Carvalho, Paulo Roberto [1] ; Rabelo Buzalaf, Marilia Afonso [3] ; Fagundes, Ticiane Cestari [1]
Total Authors: 6
[1] Sao Paulo State Univ, Aracatuba Sch Dent, Jose Bonifacio St 1193, BR-16015050 Aracatuba, SP - Brazil
[2] Oregon Hlth & Sci Univ, SW Sam Jackson Pk Rd 3181, Portland, OR 97239 - USA
[3] Univ Sao Paulo, Bauru Sch Dent, Alameda Dr Octavio Pinheiro Brisolla St 9-75, BR-17012901 Bauru, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 0

Objectives To evaluate different restorative techniques for non-carious cervical lesions (NCCLs) and the activity of matrix metalloproteinases (MMPs) in gingival crevicular fluid. Materials and methods Two hundred restorations were performed in 50 patients using resin composite restorative system without (I) and with selective enamel conditioning (II) and resin-modified glass-ionomer cement without (III) and with EDTA pretreatment (IV). Gingival crevicular fluid samples were collected in 15 patients. Restorations were evaluated using USPHS criteria at baseline and after 2 years. Percentages of MMP activity were assessed by zymography as a surrogate outcome. Equality tests of two proportions, logistic regression analysis, survival analysis, ANOVA repeated measures, and Fisher tests were used. Results No differences in clinical performance were found among groups. Group I had lower retention at 2 years than at baseline. Decreased alpha scores for marginal integrity and marginal discoloration were observed for all groups after 2 years. MMP-2 decreased after 1 year, and its activity increased back to the initial level after 2 years, mainly for groups I, II, and III. MMP-9 increased after 1 year, and it was reduced to the initial level after 2 years, mainly for group I. Conclusions All restorative techniques performed similarly in NCCLs after 2 years with initial marginal defect alterations. MMP-2 reestablished its initial levels after 2 years, and MMP-9 had few alterations over time in crevicular fluid. (AU)

FAPESP's process: 14/07086-0 - Clinical study of different strategies of adhesion in non-carious cervical lesions
Grantee:Ticiane Cestari Fagundes
Support Opportunities: Regular Research Grants