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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exercise training reduces sympathetic nerve activity and improves executive performance in individuals with obstructive sleep apnea

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Author(s):
Goya, Thiago Tanaka [1] ; Ferreira-Silva, Rosyvaldo [2] ; Gara, Elisangela Macedo [2] ; Guerra, Renan Segalla [1] ; Ferreira Barbosa, Eline Rozaria [1] ; Toschi-Dias, Edgar [1] ; Cunha, Paulo Jannuzzi [3, 4] ; Negrao, Carlos Eduardo [1, 5] ; Lorenzi-Filho, Geraldo [1] ; Ueno-Pardi, Linda Massako [2, 3, 1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Intituto Coracao InCor, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Escola Artes Ciencias & Humanidades, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Nucleo Apoio Pesquisa Neurociencia Aplicada NAPNA, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Dept Psiquiatria, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Escola Educ Fis & Esportes, Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Clinics; v. 76, 2021.
Web of Science Citations: 0
Abstract

OBJECTIVE: To investigate the effects of exercise training (ET) on muscle sympathetic nerve activity (MSNA) and executive performance during Stroop Color Word Test (SCWT) also referred to as mental stress test. METHODS: Forty-four individuals with obstructive sleep apnea (OSA) and no significant co-morbidities were randomized into 2 groups; 15 individuals completed the control period, and 18 individuals completed the ET. Mini-mental state of examination and intelligence quotient were also assessed. MSNA assessed by microneurography, heart rate by electrocardiography, blood pressure (automated oscillometric device) were measured at baseline and during 3 min of the SCWT. Peak oxygen uptake (VO2 peak) was evaluated using cardiopulmonary exercise testing. Executive performance was assessed by the total correct responses during 3 min of the SCWT. ET consisted of 3 weekly sessions of aerobic exercise, resistance exercises, and flexibility (72 sessions, achieved in 40±3.9 weeks). RESULTS: Baseline parameters were similar between groups. Heart rate, blood pressure, and MSNA responses during SCWT were similar between groups (p>0.05). The comparisons between groups showed that the changes in VO2 (4.7±0.8 vs -1.2±0.4) and apnea-hypopnea index (-7.4±3.1 vs 5.5±3.3) in the exercise-trained group were significantly greater than those observed in the control group respectively (p<0.05) after intervention. ET reduced MSNA responses (p<0.05) and significantly increased the number of correct answers (12.4%) during SCWT. The number of correct answers was unchanged in the control group (p>0.05). CONCLUSIONS: ET improves sympathetic response and executive performance during SCWT, suggesting a prominent positive impact of ET on prefrontal functioning in individuals with OSA. ClinicalTrials.gov: NCT002289625. (AU)

FAPESP's process: 10/15064-6 - Effects of exercise training on structure and cerebral metabolism, cognition and neurovascular control in individuals with obstructive sleep apnea
Grantee:Linda Massako Ueno Pardi
Support Opportunities: Regular Research Grants