| Full text | |
| Author(s): |
Mercante, Luiza A.
[1]
;
Pavinatto, Adriana
[2]
;
Pereira, Tamires S.
[3, 4]
;
Migliorini, Fernanda L.
[4]
;
dos Santos, Danilo M.
[4]
;
Correa, Daniel S.
[3, 4]
Total Authors: 6
|
| Affiliation: | [1] Fed Univ Bahia UFBA, Inst Chem, BR-40170280 Salvador, BA - Brazil
[2] Univ Brasil, Sci & Technol Inst Brazil Univ, BR-08230030 Sao Paulo, SP - Brazil
[3] Fed Univ Sao Carlos UFSCar, Ctr Exact Sci & Technol, Dept Chem, PPGQ, BR-13565905 Sao Carlos, SP - Brazil
[4] Embrapa Instrumentacao, Nanotechnol Natl Lab Agr LNNA, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | SENSORS AND ACTUATORS REPORTS; v. 3, NOV 2021. |
| Web of Science Citations: | 1 |
| Abstract | |
Biosensors are analytical tools that can be used as simple, real-time and effective devices in clinical diagnosis, food analysis, and environmental monitoring. In the last years, electrospun nanofiber's engineering has emerged as a possible strategy to improve the performance of biosensor devices. These nanostructures present a high surface-to-volume ratio, interconnected porous structure, low barrier to diffusion, and adjustable surface functionality. Additionally, nanofibers have also been demonstrated to work efficiently as platforms to immobilize biomolecules, providing a suitable microenvironment to biologically active molecules, which is beneficial for biosensing performance. This review aims to highlight the different strategies (e.g., adsorption, covalent binding, entrapment, and imprinting) for immobilizing functional receptors onto nanofibers surface for the development of specific and sensitive (bio)chemical assays, which can be used for a wide range of applications. The attractive features of electrospun nanofibers and the biorecognition elements properties are also presented and discussed. Finally, the current challenges and future opportunities for the design of nanofiber-based biosensing interfaces are also addressed. (AU) | |
| FAPESP's process: | 17/20973-4 - Coaxial electrospun nanofibers based on chitosan for controlled release of antibiotics and periodontic lesion treatment |
| Grantee: | Danilo Martins dos Santos |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis |
| Grantee: | Osvaldo Novais de Oliveira Junior |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 17/21791-7 - Development of electrochemical and colorimetric biosensors for detecting micotoxins |
| Grantee: | Fernanda Lanzoni Migliorini |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 20/10048-4 - Development of wearable sensors based on nanomaterials to detect fungal diseases in plants |
| Grantee: | Tamires dos Santos Pereira |
| Support Opportunities: | Scholarships in Brazil - Doctorate |