Risk factors for recurrent wheezing in preterm infants who received prophylaxis with palivizumab

Author(s):Show less -

Mariana Bueno Manini ^[1] ; Natasha Yumi Matsunaga ; Lívea Gianfrancesco ; Marina Simões Oliveira ; Maria Rosa Vieira de Carvalho ^[5] ; Gisleine Leila Martins Tengler Ribeiro ^[6] ; Eliane de Oliveira Morais ^[7] ; Maria Angela Gonçalves O. Ribeiro ^[8] ; André Moreno Morcillo ^[9] ; José Dirceu Ribeiro ; Adyléia Aparecida Dalbo Contrera Toro

Affiliation:Show less -

^[1] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Pediatria - Brasil

^[5] Universidade Estadual de Campinas - Brasil

^[6] Universidade Estadual de Campinas - Brasil

^[7] Universidade Estadual de Campinas - Brasil

^[8] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Centro de Investigação em Pediatria - Brasil

^[9] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Pediatria - Brasil

• Document type: Journal article
• Source: Jornal Brasileiro de Pneumologia; v. 47, n. 5 2021-10-15.

Abstract

ABSTRACT Objective: To determine the prevalence of recurrent wheezing (RW) in preterm infants who received prophylaxis against severe infection with respiratory syncytial virus (RSV) and to identify genetic susceptibility (atopy or asthma) and risk factors for RW. Methods: This was a cross-sectional study involving preterm infants who received prophylaxis with palivizumab at a referral center in Brazil during the first two years of age. A structured questionnaire was administered in a face-to-face interview with parents or legal guardians. Results: The study included 410 preterm infants (median age = 9 months [0-24 months]). In the sample as a whole, 111 children (27.1%; [95% CI, 22.9-31.5]) had RW. The univariate analysis between the groups with and without RW showed no differences regarding the following variables: sex, ethnicity, maternal level of education, gestational age, birth weight, breastfeeding, number of children in the household, day care center attendance, pets in the household, and smoking caregiver. The prevalence of RW was twice as high among children with bronchopulmonary dysplasia (adjusted OR = 2.08; 95% CI, 1.11-3.89; p = 0.022) and almost five times as high among those with a personal/family history of atopy (adjusted OR = 4.96; 95% CI, 2.62-9.39; p < 0.001) as among those without these conditions. Conclusions: Preterm infants who received prophylaxis with palivizumab but have a personal/family history of atopy or bronchopulmonary dysplasia are more likely to have RW than do those without these conditions. (AU)

• FAPESP's process: 16/22102-8 - Assessment of inflammatory and functional features along with risk factors associated to chronic obstructive pulmonary disease of pediatric patients
• Grantee: Adyléia Aparecida Dalbo Contrera Toro
• Support Opportunities: Regular Research Grants