| Full text | |
| Author(s): Show less - |
Bensenor, Isabela M.
[1]
;
Barbosa Junior, Fernando
[2]
;
Janovsky, Carolina Castro Porto Silva
[1]
;
Marchioni, Dirce
[3]
;
Diniz, Maria de Fatima Haueisen Sander
[4]
;
Santos, Itamar de Souza
[1]
;
de Almeida-Pititto, Bianca
[5]
;
Sgarbi, Jose Augusto
[6]
;
Molina, Maria del Carmen B.
[7]
;
Mill, Jose Geraldo
[7]
;
Lotufo, Paulo A.
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Sao Paulo, Hosp Univ, Ctr Pesquisa Clin & Epidemiol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Analyzes, ASTox Lab Analyt & Syst Toxicol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Fac Saude Publ, Sao Paulo - Brazil
[4] Univ Fed Minas Gerais, Fac Med, Belo Horizonte, MG - Brazil
[5] Univ Fed Sao Paulo, Sao Paulo - Brazil
[6] Fac Med Marilia, Div Endocrinol & Metab, Dept Med, Thyroid Unit, Sao Paulo - Brazil
[7] Univ Fed Espirito Santo, Espirito Santo - Brazil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY; v. 68, DEC 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Objectives: To evaluate urinary iodine concentration (UIC) in civil servants aged 35-74 years of the Brazilian Study of Adults Health (ELSA-Brasil) to analyze its relationship with sociodemographic, clinical risk factors, lifestyle, urinary Na and thyroid status. Design: Cross-sectional study in six Brazilian cities. Methods: This analysis included 792 participants with information about urinary iodine concentration (UIC). Thyroid status was defined by serum levels of TSH/FT4 and the current use of antithyroid drugs for treatment of overt hyperthyroidism or levothyroxine to treat overt hypothyroidism. The determination of UIC was carried out with an inductively coupled plasma mass spectrometer (ICP-MS) and was expressed as median with Interquartile Range (IQR). Results: In 792 participants, thereof 52% women, mean age was 51.9 (9.0) years. The median UIC was 219 (IQR, 166-291) for all persons studied, thereof 211 (IQR, 157-276) for women and 231 (IQR, 178-304) for men. According to the WHO classification, for all persons studied, 60% had more than adequate iodine-supply (UIC >= 200 mu g/L), 37% were adequately supplied (UIC 100-199 mu g/L) and <3% had a deficient iodine status (<100 mu g/L). In the 35-44-year age strata, which includes women of childbearing age, 23.2% of women presented less than 150 mu g/L of UIC. No differences in UIC were detected according to thyroid status. (P = 0.39) The correlation between Ur-Na and UIC showed a Spearman coefficient of 0.52 (P < 0.0001) and it was also found an association of Ur-Na with UIC: Beta of 1.76 (95% Confidence Interval (95% CI): 1.01 to 2.51. The urinary Na concentration showed a synergy with the UIC, that means medians of 57, 72, 107 and 141 mmol Na/L urine (P < 0.001) in the groups with the four UIC classes according to the WHO grading mentioned above. The very low Na content in the persons exhibiting <100 mu g/L UIC seems to reflect also a higher urine volume due to the frequent use of diuretics. The strong relationship between the urinary Na concentration and the UIC points to a dependence of the UIC on the individual consumption of iodized salt, which should be more considered in future studies. The strong relationship between the urinary Na concentration and the UIC points to a dependence of the UIC on the individual consumption of iodized salt, which should be more considered in future studies. Conclusions: Euthyroid persons were dominating by more than four fifths and no significant association was found between UIC and thyroid status. Although most of the persons studied present more than adequate iodine intake it was observed that nearly a quarter of women in childbearing age are iodine deficient. (AU) | |
| FAPESP's process: | 15/17213-2 - Incidence of thyroid subclinical and overt thyroid disorders in the Brazilian Longitudinal Study of Adult Health |
| Grantee: | Isabela Judith Martins Bensenor |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health |
| Grantee: | Fernando Barbosa Júnior |
| Support Opportunities: | Research Projects - Thematic Grants |