Incidence of thyroid subclinical and overt thyroid disorders in the Brazilian Longitudinal Study of Adult Health

• Grant number: 15/17213-2
• Support Opportunities: Research Projects - Thematic Grants
• Start date: September 01, 2016
• End date: November 30, 2020
• Field of knowledge: Health Sciences - Collective Health - Epidemiology
• Principal Investigator: Isabela Judith Martins Bensenor
• Grantee: Isabela Judith Martins Bensenor
• Host Institution: Hospital Universitário (HU). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Paulo Andrade Lotufo
• Associated researchers: Airlane Pereira Alencar ; Alessandra Carvalho Goulart ; Alexandre da Costa Pereira ; Andrei Carvalho Sposito ; Bianca de Almeida Pititto ; Itamar de Souza Santos ; Márcio Sommer Bittencourt ; Raul Dias dos Santos Filho ; Sandra Roberta Gouvea Ferreira Vivolo
• Associated research grant(s): 20/05441-9 - Mental health impact on the novel Coronavirus (COVID-19) in São Paulo State participants of the Brazilian longitudinal health study (ELSA-Brasil), AP.R
• Associated scholarship(s): 16/22077-3 - Association between the profile of risk factors for cardiovascular disease with emphasis on factors associated with diet as selenium deficiency and TSH levels/T4-free and thyroid function, BP.IC; 16/21937-9 - Overt, subclinical thyroid dysfunction and thyroid peroxidase antibody and their association with psychiatric disorders at baseline and after 4 years of follow-up of the Brazilian Longitudinal Study of Adult Health (ELSA-Brazil), BP.DD

Abstract

Cardiovascular disease is the main cause of mortality worldwide whiel the crescent importance of depression and cognitive impairment as cause of years lived without quality of life is increasing worldwide and in Brazil. The majority of cohort studies are in US/Europe focused on risk factor for cardiovascular disease. Emerging factors as subclinical and overt thyroid functions are less studied. Since the Wickham study with 2800 participants followed for more than 20 years until the more recent results of the "Framingham Heart Study" about thyroid function, there was an important increase in knowledge about the relationship between thyroid function and cardiovascular disease. However, little is known about the mechanisms of this association and if the results would be similar in other populations out of US/Europe.Few studies in Brazil evaluated prevalence of thyroid dysfunction and none evaluated incidence. ELSA-Brasil is a cohort study of 15,105 civil servants 35-74 years from 6 public institutions in Brazil. The baseline data collection (wave 1) occurred from August 2008/December 2010 and the 2nd data collection (wave 2) occurred from August 2012/December 2014. The data collection included interviews/exams. Telephone surveillance for outcomes is annual as well as linkage with official statistics databanks. In the baseline examination (wave 1) all participants had TSH values determined but free-thyroxine (FT4) was only tested in participants with an altered TSH: < 0.4mcUI/mL or >4.0 mcUI/mL. Serum samples were stored. In wave 2 no test to evaluate thyroid function was performed, but new samples of fasting serum were stored. TSH/FT4 were measured by a 3rd generation immunoenzymatic assay. Cut-off levels for FT4 were <0.8 ng/dL for hypo/>1.9 ng/dL for hyperthyroidism. Based on information about TSH, FT4 and use of medication/hormones, participants were classified as overt hyper/hypothyroidism, and subclinical hyper/hypothyroidism. To perform anti-TPO antibodies we will use a chemiluminescent assay with monoclonal antibodies (Siemens). Mental diagnoses were assessed by by Portuguese version of the Clinical Interview Schedule - Revised (CIS-R) to evaluate psychiatric disorders. We used 3 cognitive tests of the CERAD: memory learning and retention, a Semantic/Phonemic Verbal Fluency Test and Trial Making Test B (executive function). Statistical analysis: Incidence of thyroid function and anti-TPO after a 4-year follow-up will be calculated/10,000 participants. We will use Cox proportional hazards to calculate the relative risk (RR; 95% CI) as crude, adjusted for age/sex and after multivariate adjustment for confounders. The main objective of this proposal is to focuse all resources of the ELSA-Brasil to reach an internationally competitive study to evaluate the relationship between thyroid function and cardiovascular disease, risk factors associated to lipid metabolism, cognitive impairment and psychiatric disturbs. We can highlight the extension of the partnership with researches of US/Europe: University of Miami, Brown University, com o Baptist Hospital of Miami, Brigham and Women´s Hospital/Harvard Medical School e com a Johns Hopkins as well as with biotechnologies companies such as Atherotech (Birmingham, Alabama, US and Liposcience, now LabCorp (Raleigh, North Carolina, US) that did with no costs to the project the lipid profile using vertical ultracentrifugation and magnetic resonance imaging, respectively. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ISABELA M. BENSEÑOR; CAROLINA CASTRO PORTO SILVA JANOVSKY; ALESSANDRA C. GOULART; ITAMAR DE SOUZA SANTOS; MARIA DE FÁTIMA HAUEISEN SANDER DINIZ; BIANCA DE ALMEIDA-PITITTO; JOSÉ AUGUSTO SGARBI; PAULO A. LOTUFO. Incidence of TPOAb over a 4-year follow-up period: results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 65, n. 6, p. 832-840, 2021-11-22. (15/17213-2)

BENSENOR, ISABELA M.; BARBOSA JUNIOR, FERNANDO; JANOVSKY, CAROLINA CASTRO PORTO SILVA; MARCHIONI, DIRCE; DINIZ, MARIA DE FATIMA HAUEISEN SANDER; SANTOS, ITAMAR DE SOUZA; DE ALMEIDA-PITITTO, BIANCA; SGARBI, JOSE AUGUSTO; MOLINA, MARIA DEL CARMEN B.; MILL, JOSE GERALDO; et al. Urinary iodine and sodium concentration and thyroid status in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 68, DEC 2021. (15/17213-2, 18/24069-3)

BENSENOR, ISABELA M.; SGARBI, JOSE AUGUSTO; JANOVSKY, CAROLINA CASTRO PORTO SILVA; PITTITO, BIANCA ALMEIDA; DINIZ, MARIA DE FATIMA HAUEISEN SANDER; ALMEIDA, MARIA DA CONCEICAO CHAGAS DE; ALVIM, SHEILA MARIA; BARRETO, SANDHI M.; GIATTI, LUANA; DUNCAN, BRUCE B.; et al. Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 65, n. 4, p. 468-478, JUL-AUG 2021. (15/17213-2)

E.J.F. PEIXOTO DE MIRANDA; M.S. BITTENCOURT; H.L. STANIAK; R. SHAROVSKY; A.C. PEREIRA; M. FOPPA; I.S. SANTOS; P.A. LOTUFO; I.M. BENSEÑOR. Thyrotropin and free thyroxine levels and coronary artery disease: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Brazilian Journal of Medical and Biological Research, v. 51, n. 5, 2018-03-15. (15/17213-2)

ALWAN, HEBA; VILLOZ, FANNY; FELLER, MARTIN; DULLAART, ROBIN P. F.; BAKKER, STEPHAN J. L.; PEETERS, ROBIN P.; KAVOUSI, MARYAM; BAUER, DOUGLAS C.; CAPPOLA, ANNE R.; YEAP, BU B.; et al. Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies. EUROPEAN JOURNAL OF ENDOCRINOLOGY, v. 187, n. 5, p. 12-pg., 2022-11-01. (15/17213-2)

HOSHI, ROSANGELA A.; ANDREAO, V, RODRIGO; SANTOS, ITAMAR S.; DANTAS, EDUARDO M.; MILL, JOSE GERALDO; LOTUFO, PAULO A.; BENSENOR, ISABELA M.. Linear and nonlinear analyses of heart rate variability following orthostatism in subclinical hypothyroidism. MEDICINE, v. 98, n. 4, JAN 2019. (15/17213-2)

BENSENOR, ISABELA M.; PORTO SILVA JANOVSKY, CAROLINA CASTRO; GOULART, ALESSANDRA C.; SANTOS, ITAMAR DE SOUZA; HAUEISEN SANDER DINIZ, MARIA DE FATIMA; DE ALMEIDA-PITITTO, BIANCA; SGARBI, JOSE AUGUSTO; LOTUFO, PAULO A.. ncidence of TPOAb over a 4-year follow-up period: results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 65, n. 6, p. 832-840, NOV-DEC 2021. (15/17213-2)

AÍDA DE MELO SPILACK; ALESSANDRA C. GOULART; CAROLINA C. P. S. JANOVSKY; BIANCA DE ALMEIDA-PITTITO; PAULO A. LOTUFO; MÁRCIO SOMMER BITTENCOURT; GIULIANO GENEROSO; ITAMAR DE SOUZA SANTOS; ISABELA M. BENSENOR. The impact of diabetes and subclinical hypothyroidism association with coronary artery calcium: results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 68, 2024-02-05. (15/17213-2)