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Association between the profile of risk factors for cardiovascular disease with emphasis on factors associated with diet as selenium deficiency and TSH levels/T4-free and thyroid function

Grant number: 16/22077-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Health Sciences - Nutrition - Nutritional Analysis of Population
Principal researcher:Isabela Judith Martins Bensenor
Grantee:Gustavo Rosa Gentil Andrade
Home Institution: Hospital Universitário (HU). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:15/17213-2 - Incidence of thyroid subclinical and overt thyroid disorders in the Brazilian Longitudinal Study of Adult Health, AP.TEM


The aim of this study is to investigate the association between the profile of risk factors for cardiovascular disease, especially the intake of nutrients, and TSH levels / T4-free and thyroid function in adults. This is a study that uses data from the base of the longitudinal study of online health Adult (ELSA-Brazil), developed with employees of both sexes, six public institutions of higher education and research in the Northeast, South and Southeastern Brazil. In this study, dietary data collection method is QFA, validated from the application of three recalls 24 hours in a part of the sample; to evaluate thyroid function was analyzed dosing of thyrotropic hormone in all participants and free thyroxine was measured in participants with low TSH (<0.4 IU / ml) or high (> 4.0 IU / ml). The data on socioeconomic, demographic, biochemical, anthropometric and lifestyle of the sample characteristics are described by measures of central tendency for continuous variables and proportions and frequencies for categorical variables. The association between the variables of interest (nutrient intake and thyroid function) will be investigated by multiple regression models. Gross analysis will be made and adjusted for energy using the residual method. The models will be adjusted for age, sex, body mass index, smoking, systolic blood pressure, fasting insulin, treatment of hyperlipidemia, hypertension, prevention of cardiovascular disease or diabetes. In addition, there are potential adjustment variables that can be used in the present study. In all analyzes, it will be considered a level of statistical significance of 5%. The results of this study will be useful for a better understanding of the relationship between nutrient intake with thyroid dysfunction in adults, so that they can be adopted measures to control this morbidity and hence assist in reducing future problems in the population. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANDRADE, GUSTAVO R. G.; GORGULHO, BARTIRA; LOTUFO, PAULO A.; BENSENOR, ISABELA M.; MARCHIONI, DIRCE M.. Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study. NUTRIENTS, v. 10, n. 6, . (16/22077-3, 11/12256-4)

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