Rare-earth complexes with anti-inflammatory drug sulindac: Synthesis, characterization, spectroscopic and in vitro biological studies

Author(s)

Guerra, Renan Barrach ^[1] ; Galico, Diogo Alves ^[2] ; de Campos Fraga-Silva, Thais Fernanda ^[3] ; Aguiar, Julia ^[3] ; Venturini, James ^{[1, 4]} ; Bannach, Gilbert ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Sci, Chem Dept, BR-17033260 Bauru, SP - Brazil

^[2] Univ Ottawa, Dept Chem & Bimol Sci, Ottawa, ON K1N 6N5 - Canada

^[3] Sao Paulo State Univ UNESP, Sch Sci, Biol Sci Dept, Bauru, SP - Brazil

^[4] Univ Fed Mato Grosso do Sul, Sch Med, Campo Grande, MS - Brazil

• Document type: Journal article
• Source: Inorganica Chimica Acta; v. 526, OCT 1 2021.
• Web of Science Citations: 0

Abstract

New rare-earth complexes with the general formula {[}LnIII(sul)3]center dot nH2O, where sul- is the anti-inflammatory drug sulindac and Ln3+ = Ce3+, Pr3+, Gd3+, Tb3+, and Ho3+, were synthesized, characterized, and had their cytotoxic activity and anti-inflammatory profile assessed. Characterization employing elemental analysis, thermogravimetry, complexometric titration using EDTA, and differential scanning calorimetry provided the complexes stoichiometric ratio, whereas FTIR data results suggest that the carboxylate groups of sulindac molecules are coordinated to the lanthanide ions in a bidentate chelate fashion, with no sulfinyl groups (S--O) coordinated to the metal centers. Diffuse reflectance spectroscopy was employed in order to study the electronic properties of the synthesized complexes, revealing the presence of a metal-to-ligand charge-transfer on the Ce3+ complex. Additionally, cell viability and anti-inflammatory activities of the {[}Ln(sul)3]center dot nH2O compounds were studied employing human peripheral blood mononuclear cells (PBMC), and the results indicated that the treatment with {[}Ce(sul)3]center dot 4H2O significantly increased the PMBC viability at lower concentrations, and {[}Gd(sul)3]center dot 3H2O and {[}Ho(sul)3]center dot 3H2O displayed a high production of H2O2 was observed without a decrease in cell viability. (AU)

• FAPESP's process: 17/08820-8 - Synthesis and characterization of biopolymers from vegetable oils and glycerol following the principles of green chemistry
• Grantee: Gilbert Bannach
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/04096-2 - Synthesis, characterization and evaluation of biological activity of sulindac metallodrugs with lanthanides (III) in the solid state
• Grantee: Renan Barrach Guerra
• Support Opportunities: Scholarships in Brazil - Master