Effects of photobiomodulation and a physical exercise program on the expression of inflammatory and cartilage degradation biomarkers and functional capacity in women with knee osteoarthritis: a randomized blinded study

Author(s)

Vassao, Patricia Gabrielli ^[1] ; Flygare de Souza, Ana Carolina ^[2] ; da Silveira Campos, Raquel Munhoz ^{[1, 3]} ; Garcia, Livia Assis ^[4] ; Tucci, Helga Tatiana ^[2] ; Muniz Renno, Ana Claudia ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Biosci, Campus Baixada Santista, Rua Silva Jardim 136, BR-11015020 Santos, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Human Movement Sci, Campus Baixada Santista, Rua Silva Jardim 136, BR-11015020 Santos, SP - Brazil

^[3] Univ Fed Sao Paulo, Post Grad Program Interdisciplinary Hlth Sci, Campus Baixada Santista, Rua Silva Jardim 136, BR-11015020 Santos, SP - Brazil

^[4] Univ Brazil, Sci Inst & Technol Dept, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: ADVANCES IN RHEUMATOLOGY; v. 61, n. 1 OCT 16 2021.
• Web of Science Citations: 0

Abstract

Background The knee osteoarthritis (OA) is a joint disease characterized by degradation of articular cartilage that leads to chronic inflammation. Exercise programs and photobiomodulation (PBM) are capable of modulating the inflammatory process of minimizing functional disability related to knee OA. However, their association on the concentration of biomarkers related to OA development has not been studied yet. The aim of the present study is to investigate the effects of PBM (via cluster) with a physical exercise program in functional capacity, serum inflammatory and cartilage degradation biomarkers in patients with knee OA. Methods Forty-two patients were randomly allocated in 3 groups: ESP: exercise + sham PBM; EAP: exercise + PBM and CG: control group. Six patients were excluded before finished the experimental period. The analyzed outcomes in baseline and 8-week were: the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) and the evaluation of serum biomarkers concentration (IL-1 beta, IL-6, IL-8, IL-10 e TNF-alpha, and CTX-II). Results An increase in the functional capacity was observed in the WOMAC total score for both treated groups (p < 0.001) and ESP presents a lower value compared to CG (p < 0.05) the 8-week post-treatment. In addition, there was a significant increase in IL-10 concentration of EAP (p < 0.05) and higher value compared to CG (p < 0.001) the 8-week post-treatment. Moreover, an increase in IL-1 beta concentration was observed for CG (p < 0.05). No other difference was observed comparing the other groups. Conclusion Our data suggest that the physical exercise therapy could be a strategy for increasing functional capacity and in association with PBM for increasing IL-10 levels in OA knee individuals. Trial registration: ReBEC (RBR-7t6nzr). (AU)

• FAPESP's process: 16/08503-0 - Phototherapy and physical exercise program in patients with knee osteoarthritis: a triple blind randomized controlled trial.
• Grantee: Patrícia Gabrielli Vassão Alves Arakaki
• Support Opportunities: Scholarships in Brazil - Doctorate