| Grant number: | 16/05047-3 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | October 01, 2016 |
| End date: | December 31, 2018 |
| Field of knowledge: | Health Sciences - Physiotherapy and Occupational Therapy |
| Principal Investigator: | Stela Márcia Mattiello |
| Grantee: | Aline Castilho de Almeida |
| Host Institution: | Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil |
| Associated research grant: | 13/00798-2 - THE EXTRACELLULAR MATRIX IN AGING, EXERCISE AND IN THE TUMOR MICROENVIRONMENT, AP.TEM |
| Associated scholarship(s): | 16/22884-6 - Changes in strength and thigh composition in older adults with knee osteoarthritis, BE.EP.DR |
Abstract Introduction: The increase in intermuscular adipose tissue (IMAT) can contribute to muscle weakness and consequently on progression of knee OA. The prescription of exercise protocols has been used as a treatment strategy to minimize some of the bouts. Circuit training (CT) involves the combination of strength training and aerobic in the same session and has shown benefits in body composition and physical function. But the literature is unclear with respect to the influences of CT in the concentration of IMAT in the population with knee OA. Objective: To compare the influence of a 14-week CT protocol with a strength training protocol (ST) and an educational protocol on body composition and thigh IMAT concentration as well as cartilage degradation indicators and systemic inflammation and its impact on quality of life in patients with knee OA. Method: This study presents a clinical trial randomized controlled design. Will be selected 60 participants diagnosed with knee OA grades II and III, aged 40 and 65 years and BMI <30 kg / m2 will be randomly divided into three groups: participants submitted to circuit training (GTC), submitted to strength training (GTF) and not subjected to training, which will hold the educational protocol (GPE), which consist of weekly visits with guidance on healthy lifestyle. Participants in the GTC group will undergo periodization training protocols 14 weeks load progression, with sessions lasting 15 minutes in the first weeks and will arrive 35 minutes in final weeks, and added 10 minutes between heating and cooling down. The GTF will be subjected to exercise. strengthening also for 14 weeks, using training volume composed of sets and repetitions, without following the model of progression of CT charges. The CT will be performed three times a week, and ST will be performed twice a week. All participants will conduct pre and post CT variables: IMAT thigh (CT); body composition (bone densitometry - DXA), inflammatory biomarker concentrations: IL-1², IL-6, IL-10, TNF-±, leptin and adiponectin and joint degradation biomarkers (uCTX-II and SCOMP), performance tests functional (six-minute walk, sit and lift up and down stairs), muscle strength (maximum voluntary isometric contraction - CIVM), WOMAC questionnaires, and KOOS scale catastrophizing pain. During the training protocol, uCTX-II variables, sCOMP and CIVM will also be evaluated. To compare the groups the ANOVA one-way will be applied. When found significant main effects, the Bonferroni test is used to identify the statistically significant differences. To compare the collections times (pre, during and post training) for uCTX-II variables, Scomp and CIVM will be held repeated measures ANOVA with post hoc Bonferroni, and the WOMAC variables, KOOS, DXA, CT , functional testing and inflammatory cytokines (pre and post CT) will be held the paired t test. a significance level of 5% (p d 0.05) will be adopted.Keywords: intermuscular fat, circuit workouts, adipokines, quadriceps, inflammation, CT scan, physical therapy, rehabilitation | |
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