A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast

Author(s):Show less -

Shin, Wook-Geun ^{[1, 2, 3]} ; Sakata, Dousatsu ^[4] ; Lampe, Nathanael ; Belov, Oleg ^{[5, 6]} ; Tran, Ngoc Hoang ^[1] ; Petrovic, Ivan ^[7] ; Ristic-Fira, Aleksandra ^[7] ; Dordevic, Milos ^[7] ; Bernal, Mario A. ^[8] ; Bordage, Marie-Claude ^{[9, 10]} ; Francis, Ziad ^[11] ; Kyriakou, Ioanna ^[12] ; Perrot, Yann ^[13] ; Sasaki, Takashi ^[14] ; Villagrasa, Carmen ^[13] ; Guatelli, Susanna ^[15] ; Breton, Vincent ^[16] ; Emfietzoglou, Dimitris ^[12] ; Incerti, Sebastien ^[1]

Affiliation:Show less -

^[1] Bordeaux Univ, CENBG, CNRS, IN2P3, UMR 5797, F-33170 Gradignan - France

^[2] Seoul Natl Univ Hosp, Dept Radiat Oncol, Seoul 03080 - South Korea

^[3] Seoul Natl Univ Hosp, Biomed Res Inst, Seoul 03080 - South Korea

^[4] Inst Quantum Med Sci, Dept Accelerator & Med Phys, QST, Chiba 2638555 - Japan

^[5] Joint Inst Nucl Res, Veksler & Baldin Lab High Energy Phys, Dubna 141980 - Russia

^[6] Dubna State Univ, Inst Syst Anal & Management, Dubna 141982 - Russia

^[7] Univ Belgrade, Vinca Inst Nucl Sci, Belgrade 11000 - Serbia

^[8] Univ Estadual Campinas, Insitituto Fis Gleb Wataghin, BR-13083859 Campinas, SP - Brazil

^[9] Univ Toulouse III Paul Sabatier, CRCT, UMR 1037, F-31034 Toulouse - France

^[10] Univ Paul Sabatier, CRCT, INSERM, UMR 1037, F-31034 Toulouse - France

^[11] St Joseph Univ Beirut, Res Unit Math & Modeling, Beirut 10042020 - Lebanon

^[12] Univ Ioannina, Dept Med, Med Phys Lab, Ioannina 45110 - Greece

^[13] Inst Radioprotect & Siirete Nucl IRSN, BP17, F-92262 Fontenay Aux Roses - France

^[14] KEK, 1-1 Oho, Tsukuba, Ibaraki 3050801 - Japan

^[15] Univ Wollongong, Ctr Med Radiat Phys, Wollongong, NSW 2522 - Australia

^[16] Clermont Auvergne Univ, CNRS, IN2P3, LPC, F-63000 Clermont Ferrand - France

• Document type: Journal article
• Source: CANCERS; v. 13, n. 19 OCT 2021.
• Web of Science Citations: 0

Abstract

Simple Summary:\& nbsp;DNA damage caused by ionizing radiation in a human fibroblast cell evaluated by the Geant4-DNA Monte Carlo toolkit is presented. A validation study using a computational geometric human DNA model was then carried out, and the calculated DNA damage as a function of particle type and energy is presented. The results of this work showed a significant improvement on past work and were consistent with recent radiobiological experimental data, such as damage yields. This work and the developed methodology could impact a broad number of research fields in which the understanding of radiation effects is crucial, such as cancer radiotherapy, space science, and medical physics.</p> \& nbsp;</p> Accurately modeling the radiobiological mechanisms responsible for the induction of DNA damage remains a major scientific challenge, particularly for understanding the effects of low doses of ionizing radiation on living beings, such as the induction of carcinogenesis. A computational approach based on the Monte Carlo technique to simulate track structures in a biological medium is currently the most reliable method for calculating the early effects induced by ionizing radiation on DNA, the primary cellular target of such effects. The Geant4-DNA Monte Carlo toolkit can simulate not only the physical, but also the physico-chemical and chemical stages of water radiolysis. These stages can be combined with simplified geometric models of biological targets, such as DNA, to assess direct and indirect early DNA damage. In this study, DNA damage induced in a human fibroblast cell was evaluated using Geant4-DNA as a function of incident particle type (gammas, protons, and alphas) and energy. The resulting double-strand break yields as a function of linear energy transfer closely reproduced recent experimental data. Other quantities, such as fragment length distribution, scavengeable damage fraction, and time evolution of damage within an analytical repair model also supported the plausibility of predicting DNA damage using Geant4-DNA.The complete simulation chain application ``molecularDNA ``, an example for users of Geant4-DNA, will soon be distributed through Geant4.</p> (AU)

• FAPESP's process: 18/15316-7 - Study of the interaction of heavy charged particles with DNA using computational methods
• Grantee: Mario Antonio Bernal Rodriguez
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 15/21873-8 - Establishment and application of methodologies for optimizing imaging techniques in digital radiology
• Grantee: Alessandra Tomal
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/51594-2 - Development of a computational system for the simulation of the interaction of ionizing radiations with the human genetic material
• Grantee: Mario Antonio Bernal Rodriguez
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 20/08647-7 - Developments of X-ray characterization techniques and application in quantitative neuroscience
• Grantee: Jean Rinkel
• Support Opportunities: Regular Research Grants