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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effectiveness of a new rutin Cu(II) complex in the prevention of lipid peroxidation and hepatotoxicity in hypercholesterolemic rats

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Author(s):
de Oliveira, Daniel A. F. [1] ; Diniz, Susana N. [1] ; Pereira, Regina M. S. [1] ; Goncalves, Ivair D. [1] ; Renno, Andre L. [2, 3] ; Gorjao, Renata [4] ; Vieira, Eduardo G. [5] ; Ferreira, Ana M. C. [5] ; Okuyama, Cristina E. [1]
Total Authors: 9
Affiliation:
[1] Univ Anhanguera Sao Paulo UNIAN, Sao Paulo - Brazil
[2] Ctr Univ Jaguariuna UNIFAJ, Fac Pharm, Jaguariuna - Brazil
[3] Fac Sao Leopoldo Mandic SLM, Fac Med, Campinas - Brazil
[4] Univ Cruzeiro do Sul UNICSUL, Program Interdisciplinary Postgrad Hlth Sci, Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Chem, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: JOURNAL OF FOOD BIOCHEMISTRY; NOV 2021.
Web of Science Citations: 0
Abstract

A new rutin copper(II) complex (R-Cu2) was prepared and characterized by spectroscopic methods and elemental analysis. The effects of rutin and R-Cu2 were evaluated on the prevention of hypercholesterolemia in animals feed with high-cholesterol diet (HCD) for 8 weeks. The animals (n = 5) were neither fed with HCD nor treated (control group), or were treated with vehicle, 10 mg/kg simvastatin, rutin (16 and 160 mu mol/kg), and R-Cu2 (16 and 160 mu mol/kg) administered orally. Total cholesterol (TC) levels were significantly increased (p < .01) in all HCD groups. In rutin and R-Cu2 groups, it was observed a discrete, but not significant, TC and LDL-induced increase inhibition compared with vehicle-treated group. R-Cu2 treatment significantly decreased (p < .05) plasma triglycerides compared with the vehicle-treated group. All groups receiving treatments maintained the malondialdehyde at normal levels. Serum NO levels were reduced in animals treated with rutin and R-Cu2 compared with the vehicle-treated group. In addition, the results also showed that the groups treated with rutin and R-Cu2 reduced significantly (p < .01), the number of neutrophils and prevented histological changes in all evaluated liver zones. R-Cu2 group maintained the ALT, AST, and ALP enzymes at normal levels. Thus, the effects of R-Cu2 in modulating inflammation and protecting liver damage were confirmed. Practical applications Rutin, a plant-derived flavonoid, is one of phenolic compounds well known as a nutraceutical due to its antioxidant and anti-inflammatory properties. Findings of this study demonstrate the effects of both rutin and R-Cu2 in modulating inflammation and protecting liver damage in hypercholesterolemic rats. However, some effects analyzed became more evident in R-Cu2. Thereby, it was shown that the synthesis of a new flavonoid compound (R-Cu2) could be applied as a nutraceutical benefit option to prevent hypercholesterolemia condition. (AU)

FAPESP's process: 09/00344-6 - EVALUATION OF PHARMACOLOGICAL PROPERTIES OF FLAVONOIDS AND METAL-FLAVONOIDS COMPLEXES.
Grantee:Cristina Eunice Okuyama Costa
Support Opportunities: Regular Research Grants
FAPESP's process: 12/14159-9 - Synthesis, characterization and fluorescence studies of coumarins compounds containing transition metals of the first series: evaluation of their the antiparasitic potential
Grantee:Regina Mara Silva Pereira
Support Opportunities: Regular Research Grants