| Full text | |
| Author(s): |
Uehara, Thiers M.
[1]
;
Migliorini, Fernanda L.
[1]
;
Facure, Murilo H. M.
[1, 2]
;
Palma Filho, Nicolau B.
[3]
;
Miranda, Paulo B.
[3]
;
Zucolotto, Valtencir
[3]
;
Correa, Daniel S.
[1, 2]
Total Authors: 7
|
| Affiliation: | [1] Embrapa Instrumentacao, Nanotechnol Natl Lab Agr LNNA, BR-13560970 Sao Carlos, SP - Brazil
[2] Fed Univ Sao Carlos UFSCar, PPGQ, Dept Chem, Ctr Exact Sci & Technol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Phys Inst Sao Carlos, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | POLYMERS FOR ADVANCED TECHNOLOGIES; v. 33, n. 2 NOV 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
The use of graphene oxide (GO) has become widespread due to its advantageous properties for applications in medical devices, including cell scaffolds and sensors. Investigations on the spectroscopic and electrochemical features of nanostructured cell scaffolds may be of interest to design novel scaffolds architectures aimed at understanding their interactions with healthy and cancer cells. In this study, we investigated the interactions between liver cancer cells and two GO-containing scaffold platforms, namely: cells membrane models containing GO in the form of Langmuir-Blodgett films, and GO-modified biodegradable polycaprolactone nanofibers. Sum-frequency generation spectroscopy revealed the presence and formation of an expanded phospholipid monolayer underneath GO, while scanning electron microscopy images revealed the morphology of the cells on the different surfaces. Electrochemical impedance spectroscopy was employed to evaluate the charge transfer resistance in different nanostructured scaffolds containing liver cancer cells. The nanosystems developed here can be applied to study the interactions between cells on polymer nanofibers and Langmuir-Blodgett films modified with GO for regenerative medicine. (AU) | |
| FAPESP's process: | 17/12174-4 - Development of hybrid polymer nanofibers for agricultural applications |
| Grantee: | Daniel Souza Corrêa |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/10582-8 - Production and characterization of graphene quantum dots and their application in chemical sensors |
| Grantee: | Murilo Henrique Moreira Facure |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 18/02819-0 - Interaction of chitosans and surfactants with cell membrane models investigated by nonlinear vibrational spectroscopy |
| Grantee: | Paulo Barbeitas Miranda |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/21791-7 - Development of electrochemical and colorimetric biosensors for detecting micotoxins |
| Grantee: | Fernanda Lanzoni Migliorini |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis |
| Grantee: | Osvaldo Novais de Oliveira Junior |
| Support Opportunities: | Research Projects - Thematic Grants |