The influence of nutrigenetics on biomarkers of selenium nutritional status

Author(s)

Donadio, Janaina L. S. ^{[1, 2]} ; Duarte, Graziela B. S. ^[2] ; Borel, Patrick ^[3] ; Cozzolino, Silvia M. F. ^[2] ; Rogero, Marcelo M. ^{[4, 1]}

Affiliation

^[1] Sao Paulo Res Fdn, Food Res Ctr FoRC, CEPID FAPESP Res Innovat & Disseminat Ctr, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Av Prof Lineu Prestes 580, BR-05508900 Sao Paulo - Brazil

^[3] Aix Marseille Univ, INSERM, INRAE, C2VN, Marseille - France

^[4] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil

• Document type: Review article
• Source: NUTRITION REVIEWS; v. 79, n. 11, p. 1259-1273, NOV 2021.
• Web of Science Citations: 0

Abstract

Selenium (Se) is an essential micronutrient for human biology that executes its functions as the amino acid selenocysteine via selenoproteins, which have important functions in, for example, antioxidation, immunomodulation, thyroid metabolism, and human fertility. Se nutritional status is assessed using the quantification of blood Se biomarkers, which are influenced by several factors, including diet, age, gender, smoking status, alcohol consumption, health condition, and the genetic characteristics of individuals. Nutrigenetic studies have identified single nucleotide polymorphisms in selenoproteins that might clarify the high variability in values reported for biomarkers of Se nutritional status in different populations, and the response of these biomarkers to Se supplementation with either organic or inorganic forms of Se. This review aims to (1) define the basic aspects of Se biology, (2) describe the current most commonly used biomarkers of Se nutritional status, and (3) provide a summary of associations between functional single nucleotide polymor-phisms in selenoproteins and biomarkers of Se status in healthy populations. (AU)

• FAPESP's process: 15/10146-8 - Influence of genetic polymorphisms in SEPP1 gene on SePP and GPx3 concentrations after Brazil nut supplementation
• Grantee: Janaina Lombello Santos Donadio
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 11/17720-0 - Influence of diferents genotypes in the pattern of selenoproteins expression in response to selenium supplementation
• Grantee: Janaina Lombello Santos Donadio
• Support Opportunities: Scholarships in Brazil - Doctorate