| Full text | |
| Author(s): |
Santos, Ralmony de Alcantara
[1]
;
Guzzoni, Vinicius
[2]
;
Silva, Kleiton Augusto Santos
[1, 3]
;
Aragao, Danielle Sanches
[1]
;
Vieira, Rodolfo de Paula
[2]
;
Bertoncello, Nadia
[2]
;
Schor, Nestor
[1]
;
Aimbire, Flavio
[2]
;
Casarini, Dulce Elena
[1]
;
Cunha, Tatiana Sousa
[2]
Total Authors: 10
|
| Affiliation: | [1] Univ Fed Sao Paulo, Dept Med, Nephrol Div, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Inst Sci & Technol, Sao Jose Dos Campos - Brazil
[3] Univ Missouri, Dept Biomed Sci, Columbia, MO - USA
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Life Sciences; v. 287, DEC 15 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Aims: We aimed to determine whether resistance training (RT) regulates renal renin-angiotensin system (RAS) components and inflammatory mediators in diabetic rats. Main methods: Male Wistar rats (3 months old) were randomly assigned into four groups: non-trained (NT), trained (T), non-trained + diabetes (NTD) and trained +diabetes (TD). Diabetes was induced by streptozotocin (50 mg/kg, Sigma Chemical Co., St. Louis, MO, USA), before RT protocol. Trained rats performed RT protocol on a 110-cm ladder (8 ladder climbs, once/day, 5 days/week, 8 weeks), carrying a load corresponding to 50-80% of maximum carrying capacity. Blood glucose, albuminuria and urinary volume were measured. Renal levels of angiotensin peptides (angiotensin I, II and 1-7), inflammatory markers, and also the activities of angiotensinconverting enzyme (ACE) and ACE2 were determined. Key findings: Blood glucose and urinary volume were elevated in diabetic animals, and RT decreased albuminuria, renal Ang I and Ang II levels in diabetic rats. RT shifted the balance of renal RAS toward ACE2/Ang 1-7 axis in TD group, and mitigated the high levels of interleukin (IL)-10, IL-1 beta and cytokine-induced neutrophil chemoattractant 1 (CINC) in the context of diabetes. Strong positive correlations were found between albuminuria and Ang II, IL-10 and IL-1 beta. On the other hand, intrarenal Ang 1-7 levels were negatively correlated with IL-10 and IL-1 beta levels. Significance: RT improved kidney function by modulating intrarenal RAS toward ACE2/Ang 1-7 axis and inflammatory cytokines. RT represents a reasonable strategy to improve the renal complications induced by diabetes, counteracting nephropathy-associated maladaptive responses. (AU) | |
| FAPESP's process: | 13/20034-7 - Evaluation of the effects of resistance and aerobic exercise training on diabetic cardiomyopathy: participation of signaling pathways of energy metabolism and the renin-angiotensin system |
| Grantee: | Ralmony de Alcantara Santos |
| Support Opportunities: | Scholarships in Brazil - Doctorate |