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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Zebrafish as a translational model: an experimental alternative to study the mechanisms involved in anosmia and possible neurodegenerative aspects of COVID-19?

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Author(s):
Costal, Karla C. M. [1] ; Brigante, Tamires A. V. [1] ; Fernandes, Gabriel G. [1] ; Scomparin, Davi S. [1] ; Scarante, Franciele F. [1] ; de Oliveira, Danielle P. [2] ; Campos, Alline C. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Med, Dept Pharmacol Ribeirao Preto, Pharmacol Neuroplast Lab, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, EcoHumanTox Lab, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: ENEURO; v. 8, n. 3 MAY-JUN 2021.
Web of Science Citations: 0
Abstract

The Coronavirus Disease - 2019 (COVID-19) presents a variability of clinical symptoms, ranging from asymptomatic to severe respiratory and systemic conditions. In a cohort of patients, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), beyond the classical respiratory manifestations, induces anosmia. Evidence has suggested SARS-CoV-2-induced anosmia can be the result of neurodegeneration of the olfactory pathway. Neurological symptoms associated with COVID-19 have been reported; however, the precise mechanism and possible long-lasting effects remain poorly investigated. Preclinical models are valuable tools for describing and testing new possible treatments for neurological disorders. In this way, the zebrafish (Danio rerio) organism model represents an attractive tool in the field of neuroscience, showing economic and logistical advantages besides genetic and physiologic similarities with mammalian, including the brain structure and functions. Besides, its external embryonic development, high availability of eggs, and fast development allows easy genetic manipulation and fast replications. In the present review, we suggest that the zebrafish model can be advantageous to investigate the neurological features of COVID-19. SIGNIFICANCE STATEMENT The Coronavirus Disease - 2019 (COVID-19) is characterized not only by respiratory, but also neurological symptoms that may persevere even longer than the respiratory condition. However, some questions remain unanswered. How does the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) enter the brain? Which brain regions are infected? How does the virus affect our behavioral and sensorial responses? Can the brain infection induce alterations that last longer? We propose that the zebrafish is a suitable model to study the effects of SARS-CoV-2 in the brain, especially because of the similarities between the fish' and the human brain. Zebrafish is a cheap animal model and several reproducible and fast animal tests can be used to investigate its behavioral and sensory functions. (AU)

FAPESP's process: 18/24298-2 - USE OF MULTI-BIOMARkER STRATEGY IN ZEBRAFISH AS A PLATFORM TO ESTIMATE NEUROCOMPORTAMENTAL EFFECTS INDUCED BY FLAME RETARDANTS
Grantee:Danielle Palma de Oliveira
Support Opportunities: Regular Research Grants
FAPESP's process: 20/05416-4 - Experimental strategies in the context of COVID-19-induced anosmia: is neurodegeneration involved?
Grantee:Alline Cristina de Campos
Support Opportunities: Regular Research Grants