lusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccine

Author(s):Show less -

de Souza, William M. ^{[1, 2]} ; Muraro, Stefanie P. ^[3] ; Souza, Gabriela F. ^[3] ; Amorim, Mariene R. ^[3] ; Sesti-Costa, Renata ^{[4, 5]} ; Mofatto, Luciana S. ^[3] ; Forato, Julia ^[3] ; Barbosa, Priscilla P. ^[3] ; Toledo-Teixeira, Daniel A. ^[3] ; Bispo-dos-Santos, Karina ^[3] ; Parise, Pierina L. ^[3] ; Brunetti, Natalia S. ^[6] ; Moreira, Joselia C. O. ^[7] ; Costa, Vitor A. ^[5] ; Cardozo, Daniela M. ^[8] ; Moretti, Maria L. ^[9] ; Barros-Mazon, Silvia ^[8] ; Marchesi, Gabriela F. ^[10] ; Ambrosio, Christiane ^[10] ; Spilki, Fernando R. ^[11] ; Almeida, Valeria C. ^[10] ; Vieira, Andre S. ^[7] ; Zambon, Lair ^[9] ; Farias, Alessandro S. ^{[12, 13]} ; Addas-Carvalho, Marcelo ^[5] ; Benites, Bruno D. ^[5] ; Marques, Rafael E. ^[4] ; Sabino, Ester C. ^{[14, 15]} ; Von Zuben, Andrea B. ; Weaver, Scott C. ^{[16, 1]} ; Faria, Nuno R. ^{[17, 14, 18]} ; Granja, Fabiana ^[19] ; Angerami, Rodrigo N. ^{[9, 10]} ; Proenca-Modena, Jose Luiz ^{[13, 3]}

Affiliation:Show less -

^[1] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 - USA

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Virol Res Ctr, BR-14049900 Ribeirao Preto - Brazil

^[3] Univ Estadual Campinas, Inst Biol, Dept Genet, Lab Emerging Viruses, BR-13083862 Campinas - Brazil

^[4] Brazilian Ctr Res Energy & Mat, Brazilian Biosci Natl Lab, BR-13083100 Campinas - Brazil

^[5] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, BR-13083862 Campinas - Brazil

^[6] Univ Estadual Campinas, Inst Biol, Dept Genet, Autoimmune Res Lab, BR-13083862 Campinas - Brazil

^[7] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, BR-13083862 Campinas - Brazil

^[8] Univ Estadual Campinas, Sch Med Sci, Dept Clin Pathol, BR-13083862 Campinas - Brazil

^[9] Univ Estadual Campinas, Sch Med Sci, Dept Internal Med, BR-13083862 Campinas - Brazil

^[10] Campinas Dept Publ Hlth Surveillance, BR-13015904 Campinas - Brazil

^[11] Feevale Univ, One Hlth Lab, BR-93510235 Novo Hamburgo - Brazil

^[12] Univ Estadual Campinas, Obes & Comorbid Res Ctr, BR-13083862 Campinas - Brazil

^[13] Univ Estadual Campinas, Expt Med Res Cluster, BR-13083862 Campinas - Brazil

^[14] Univ Sao Paulo, Sch Med, Dept Infect & Parasit Dis, BR-05403000 Sao Paulo - Brazil

^[15] Univ Sao Paulo, Inst Trop Med, Sch Med, BR-05403907 Sao Paulo - Brazil

^[16] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 - USA

^[17] Univ Oxford, Dept Zool, Oxford OX1 2JD - England

^[18] Imperial Coll London, MRC Ctr Global Infect Dis Anal, J IDEA, London SW7 2AZ - England

^[19] Univ Fed Roraima, Biodivers Res Ctr, BR-72000000 Boa Vista, Parana - Brazil

• Document type: Journal article
• Source: Viruses-Basel; v. 13, n. 11 NOV 2021.
• Web of Science Citations: 1

Abstract

A SARS-CoV-2 B.1.1.7 variant of concern (VOC) has been associated with increased transmissibility, hospitalization, and mortality. This study aimed to explore the factors associated with B.1.1.7 VOC infection in the context of vaccination. On March 2021, we detected SARS-CoV-2 RNA in nasopharyngeal samples from 14 of 22 individuals vaccinated with a single-dose of ChAdOx1 (outbreak A, n = 26), and 22 of 42 of individuals with two doses of the CoronaVac vaccine (outbreak B, n = 52) for breakthrough infection rates for ChAdOx1 of 63.6% and 52.4% for CoronaVac. The outbreaks were caused by two independent clusters of the B.1.1.7 VOC. The serum of PCR-positive symptomatic SARS-CoV-2-infected individuals had \~{}1.8-3.4-fold more neutralizing capacity against B.1.1.7 compared to the serum of asymptomatic individuals. These data based on exploratory analysis suggest that the B.1.1.7 variant can infect individuals partially immunized with a single dose of an adenovirus-vectored vaccine or fully immunized with two doses of an inactivated vaccine, although the vaccines were able to reduce the risk of severe disease and death caused by this VOC, even in the elderly. (AU)

• FAPESP's process: 16/00194-8 - Pathogenesis and neurovirulence of emerging viruses in Brazil
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