Multi-omic approaches for the study of Chikungunya disease

• Grant number: 19/24251-9
• Support type: Scholarships abroad - Research Internship - Post-doctor
• Effective date (Start): July 31, 2020
• Effective date (End): June 26, 2021
• Field of knowledge: Biological Sciences - Microbiology
• Principal researcher: Luiz Tadeu Moraes Figueiredo
• Grantee: William Marciel de Souza
• Supervisor abroad: Nuno Miguel Rodrigues Pascoal Faria
• Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Research place: University of Oxford, England
• Associated to the scholarship: 17/13981-0 - Characterization, genomics and diagnostic of viruses with importance for public health in Brazil by high throughput sequencing, BP.PD

Abstract

Chikungunya virus (CHIKV) causes acute and often symptomatic infections that are associated with fever and debilitating polyarthralgia/polyarthritis. CHIKV infection has also been associated with high lethality among elderly patients with preexisting conditions. Surprisingly, over 25% of CHIKV-related deaths in the Americas have been reported in Fortaleza city, Ceará State, Brazil. In this context, this project aims to understand the evolutionary and pathogenesis mechanisms associated with CHIKV-related deaths. To achieve this, we will perform a multi-platform omics analysis of peripheral samples recovered from different body compartments of fatal and non-fatal CHIKV patients to identify key virus-host interactions and biomarkers underlying disease severity. We will conduct extensive studies of CHIKV genetic diversity across viral genomes to identify selective pressures and hotspots of virus diversity along the genome that may be associated with disease severity. Finally, we will create a data-centric bioinformatic environment for the visualization of genomic, clinical and epidemiological data related to arbovirus circulation in Brazil. This study will shed light into the mechanisms underlying CHIKV severity, and will provide a valuable community resource for the analysis of genomic, clinical and epidemiological data on arboviruses circulating in Brazil.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CANDIDO, DARLAN S.; CLARO, INGRA M.; DE JESUS, JAQUELINE G.; SOUZA, WILLIAM M.; MOREIRA, FILIPE R. R.; DELLICOUR, SIMON; MELLAN, THOMAS A.; DU PLESSIS, LOUIS; PEREIRA, RAFAEL H. M.; SALES, FLAVIA C. S.; MANULI, ERIKA R.; THEZE, JULIEN; ALMEIDA, LUIZ; MENEZES, MARIANE T.; VOLOCH, CAROLINA M.; FUMAGALLI, MARCILIO J.; COLETTI, THAIS M.; SILVA, CAMILA A. M.; RAMUNDO, MARIANA S.; AMORIM, MARIENE R.; HOELTGEBAUM, HENRIQUE H.; MISHRA, SWAPNIL; GILL, MANDEV S.; CARVALHO, LUIZ M.; BUSS, LEWIS F.; PRETE JR, CARLOS A.; ASHWORTH, JORDAN; NAKAYA, I, HELDER; PEIXOTO, PEDRO S.; BRADY, OLIVER J.; NICHOLLS, SAMUEL M.; TANURI, AMILCAR; ROSSI, ATILA D.; BRAGA, V, CARLOS K.; GERBER, ALEXANDRA L.; GUIMARAES, ANA PAULA DE C.; GABURO JR, NELSON; ALENCAR, CECILA SALETE; FERREIRA, ALESSANDRO C. S.; LIMA, CRISTIANO X.; LEVI, JOSE EDUARDO; GRANATO, CELSO; FERREIRA, GIULIA M.; FRANCISCO JR, RONALDO S.; GRANJA, FABIANA; GARCIA, MARCIA T.; MORETTI, MARIA LUIZA; PERROUD JR, MAURICIO W.; CASTINEIRAS, TEREZINHA M. P. P.; LAZARI, CAROLINA S.; HILL, SARAH C.; DE SOUZA SANTOS, ANDREZA ARUSKA; SIMEONI, CAMILA L.; FORATO, JULIA; SPOSITO, ANDREI C.; SCHREIBER, ANGELICA Z.; SANTOS, MAGNUN N. N.; DE SA, CAMILA ZOLINI; SOUZA, RENAN P.; RESENDE-MOREIRA, LUCIANA C.; TEIXEIRA, MAURO M.; HUBNER, JOSY; LEME, PATRICIA A. F.; MOREIRA, RENNAN G.; NOGUEIRA, MAURICIO L.; FERGUSON, NEIL M.; COSTA, SILVIA F.; PROENCA-MODENA, JOSE LUIZ; VASCONCELOS, ANA TEREZA R.; BHATT, SAMIR; LEMEY, PHILIPPE; WU, CHIEH-HSI; RAMBAUT, ANDREW; LOMAN, NICK J.; AGUIAR, RENATO S.; PYBUS, OLIVER G.; SABINO, ESTER C.; FARIA, NUNO RODRIGUES; DISCOVERY, BRAZIL-UK CTR ARBOVIRUS. Evolution and epidemic spread of SARS-CoV-2 in Brazil. Science, v. 369, n. 6508, SI, p. 1255+, SEP 4 2020. Web of Science Citations: 1.

DE SOUZA, WILLIAM MARCIEL; BUSS, LEWIS FLETCHER; CANDIDO, DARLAN DA SILVA; CARRERA, JEAN-PAUL; LI, SABRINA; ZAREBSKI, ALEXANDER E.; PEREIRA, RAFAEL HENRIQUE MORAES; PRETE, JR., CARLOS A.; DE SOUZA-SANTOS, ANDREZA ARUSKA; PARAG, KRIS V.; BELOTTI, MARIA CAROLINA T. D.; VINCENTI-GONZALEZ, MARIA F.; MESSINA, JANEY; DA SILVA SALES, FLAVIA CRISTINA; ANDRADE, PAMELA DOS SANTOS; NASCIMENTO, VITOR HELOIZ; GHILARDI, FABIO; ABADE, LEANDRO; GUTIERREZ, BERNARDO; KRAEMER, MORITZ U. G.; BRAGA, CARLOS K. V.; AGUIAR, RENATO SANTANA; ALEXANDER, NEAL; MAYAUD, PHILIPPE; BRADY, OLIVER J.; MARCILIO, IZABEL; GOUVEIA, NELSON; LI, GUANGDI; TAMI, ADRIANA; DE OLIVEIRA, SILVANO BARBOSA; PORTO, VICTOR BERTOLLO GOMES; GANEM, FABIANA; DE ALMEIDA, WALQUIRIA APARECIDA FERREIRA; FANTINATO, FRANCIELI FONTANA SUTILE TARDETTI; MACARIO, EDUARDO MARQUES; DE OLIVEIRA, WANDERSON KLEBER; NOGUEIRA, MAURICIO L.; PYBUS, OLIVER G.; WU, CHIEH-HSI; CRODA, JULIO; SABINO, ESTER C.; FARIA, NUNO RODRIGUES. Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil. NATURE HUMAN BEHAVIOUR, v. 4, n. 8 JUL 2020. Web of Science Citations: 0.