Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Incidence of dementia in a population cohort of older people from Sao Paulo, Brazil

Full text
Author(s):
Lopes, Marcos Antonio [1] ; Nassar, Silvia Modesto [2] ; Barcelos-Ferreira, Ricardo [3] ; Folquitto, Jefferson Cunha [4] ; Litvoc, Julio [5]
Total Authors: 5
Affiliation:
[1] Univ Fed Santa Catarina, Internal Med Dept, Florianopolis, SC - Brazil
[2] Univ Fed Santa Catarina, Informat & Stat Dept, Florianopolis, SC - Brazil
[3] Univ Fed Juiz de Fora, Internal Med Dept, Juiz De Fora - Brazil
[4] Univ Sao Paulo, Psychiat Inst, Old Age Res Grp, Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Med, Prevent Med Dept, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY; NOV 2021.
Web of Science Citations: 0
Abstract

Objectives To estimate the incidence of dementia in a community-dwelling older population from Sao Paulo city, Brazil. Methods/Design This two-phase prospective cohort study evaluated a representative cluster sample of 1370 individuals aged 60 years old and over from three different socioeconomic levels. The community screening phase consisted of a tested combination of cognitive and functional tests administered among the subjects and informants. In the hospital diagnosis phase, the Cambridge Examination was performed; the diagnosis of dementia and dementia subtypes was made according to DSM IV criteria. Incidence rates were expressed in person-years, multiplied by 1000. The risk of developing dementia was calculated using Cox regression. Results Among 1370 eligible subjects, 678 were accessed, and 489 completed the evaluation. Forty-two subjects were diagnosed with dementia. The incidence rate of dementia and Alzheimer's disease (AD) were 11.2 (95% CI: 8.0-15.1) and 8.9 (95% CI: 6.1-12.5) per 1000 person-years, respectively; there were high age-specific rates of dementia among younger individuals. There was a trend of a higher risk of developing AD for women than for men. Multivariate analysis showed that older age, the presence of diabetes and the presence of amnestic MCI increased the risk of developing dementia. Conclusions The age-specific rates in younger individuals were expressively higher than in worldwide studies and supposedly affected by cardiovascular morbidity. The higher risk in women in a younger sample corroborated the interaction between sex and AD. The increased risk of amnestic MCI reinforced its contribution to the progression to dementia and AD. (AU)