esign of polyurea networks containing anticancer and anti-inflammatory drugs for dual drug delivery purpose

Author(s)

de Resende, Mariane A. ^[1] ; Pedroza, Gabriele A. ^[1] ; Macedo, Lucia H. G. M. C. ^[1] ; de Oliveira, Ricardo ^[1] ; Amela-Cortes, Maria ^[2] ; Molard, Yann ^[2] ; Molina, Eduardo F. ^[1]

Affiliation

^[1] Univ Franca, Dept Chem, Franca, SP - Brazil

^[2] Univ Rennes, CNRS, ISCR UMR 6226, ScanMAT UMS 2001, Rennes - France

• Document type: Journal article
• Source: Journal of Applied Polymer Science; v. 139, n. 16 NOV 2021.
• Web of Science Citations: 0

Abstract

Naproxen (Nap), a non-steroidal anti-inflammatory drug, and 5-fluorouracil (5FU), an anticancer drug, were easily incorporated into a polyurea xerogel. Polyureas (PUr) were synthesized by one pot reaction via sol-gel chemistry. Soft segments were based on polyetheramine-PEO and hard segments were based on a hexamethylene diisocyanate trimer (HDI). The final materials were characterized by Fourier transform infrared (FTIR) spectroscopy, small-angle X-ray scattering (SAXS), and differential scanning calorimetry (DSC). Polyurea can assume many forms revealing its versatility in terms of produced shapes. In good agreement with FTIR, SAXS studies showed a microphase separated structure arising from inter-hard-domain spacings, which remains unchanged after incorporation of the drugs. DSC analysis demonstrated that the PEO chain mobility was poorly affected after the drugs incorporation due to the solvation of the drugs through the network. The water uptake and the amount of drug released agree well, playing an important role for controlled Nap and 5FU release. This work opens positive perspectives for ocular drug delivery and wound management, due to the easy processability of the xerogel, which has high feasibility to be moldable as pharmaceutical devices for contact lenses and transdermal patches purposes containing distinct therapeutic agents. (AU)

• FAPESP's process: 19/17860-9 - Bioadhesive film formed from polyurea for transdermal drug delivery system
• Grantee: Gabriele Pedroza Andrade
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 20/06531-1 - Polyurea matrix based on polyethylene PEO for naproxen drug delivery system
• Grantee: Mariane Aparecida de Resende
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 17/50286-9 - Nanoclusters containing hybrid membranes for sensing and lighting clustobrane
• Grantee: Eduardo Ferreira Molina
• Support Opportunities: Regular Research Grants