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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Vibrational Circular Dichroism for the Assignment of Absolute Configuration of Natural Products in Brazil

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Author(s):
Batista, Andrea N. L. [1] ; dos Santos Jr, Fernando M. ; Valverde, Alessandra L. [2] ; Batista Jr, Joao M.
Total Authors: 4
Affiliation:
[1] Univ Fed Fluminense, Inst Quim, Dept Quim Organ, Outeiro Sao Joao Batista S-N, BR-24020141 Niteroi, RJ - Brazil
[2] dos Santos Jr, Jr., Fernando M., Univ Fed Fluminense, Inst Quim, Dept Quim Organ, Outeiro Sao Joao Batista S-N, BR-24020141 Niteroi, RJ - Brazil
Total Affiliations: 2
Document type: Review article
Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 31, n. 5 DEC 2021.
Web of Science Citations: 0
Abstract

The determination of the absolute configuration of chiral bioactive natural products is a crucial step in their structural characterization. Several well-established techniques, such as X-ray crystallography, stereo-controlled organic synthesis, NMR, and chiroptical spectroscopy, are commonly used to this end. However, even today, the configurational analysis of natural products remains a challenge, with a significant number of reassignments being reported every year. Among chiroptical methods, vibrational circular dichroism (VCD) has emerged as an excellent tool for the assignment of the absolute configuration of structurally diverse chiral natural products directly in solution. This review covers the use of VCD spectroscopy to elucidate the absolute stereochemistry of natural products in Brazil over the last 20 years. Although the number of VCD investigations on secondary metabolites has increased, VCD can still be considered under-explored in Brazil. Therefore, herein, we aim to demonstrate the unparalleled stereochemical discriminatory power of VCD to assign both conformation and absolute configuration of natural products in conditions not commonly accessible to other techniques. (AU)

FAPESP's process: 19/22319-5 - Vibrational circular dichroism spectral markers: facilitating absolute configuration assignment of natural products
Grantee:João Marcos Batista Junior
Support Opportunities: Regular Research Grants