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Vibrational chiroptical spectroscopy for stereochemical characterization of small molecules and macromolecules


Vibrational circular dichroism (VCD) and Raman optical activity (ROA), collectively know as vibrational optical activity (VOA), are powerful spectroscopic methods for the characterization of tridimensional structure of small molecules and macromolecules, as well as their interactions in solution. By combining the richness of spectral information from IR and Raman spectroscopies with sensitivity to chirality, VCD and ROA become excellent tools for determining the absolute configuration of small molecules and secondary structure of macromolecules. Despite their positive characteristics, both techniques are scantily used in Brazil. Therefore, the main goal of this project is to create the first VOA research group in the country in the Department of Chemistry at UFSCar, in order to determine the absolute configuration of natural and synthetic compounds, as well as to conduct systematic studies on the mechanisms of interaction between analytes and stationary phases used in classic chiral liquid chromatography and bioaffinity chromatography. This proposal is intended to combine the expertise of the proponent in VOA and quantum-chemical calculations with the demand for stereochemical analysis of two groups of excellence at UFSCar headed by Profs. Quezia B. Cass and Maria Fátima G. F. da Silva. Finally, this proposal aims to contribute to the development of high-quality human resources at UFSCar and also to boost the internationalization of São Paulo State research, since Prof. Laurence A. Nafie from Syracuse University, one of the world's leading researchers in the field will be part of the research team. (AU)

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Scientific publications (26)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CALISTO, ITALO H.; FURLAN, MAYSA; BLANCH, EWAN W.; BATISTA, JR., JOAO M.. Raman optical activity of a flavone C-diglycoside: Aqueous solution conformations and absolute configuration. VIBRATIONAL SPECTROSCOPY, v. 91, n. SI, p. 136-140, . (15/07089-2, 14/25222-9)
FRANCESCHINI SARRIA, ANDRE LUCIO; SILVA, TAYNARA LOPES; DE OLIVEIRA, JULIANA MAGALHAES; RODRIGUES DE OLIVEIRA, MILENE APARECIDA; FERNANDES, JOAO BATISTA; DAS GRACAS FERNANDES DA SILVA, MARIA FATIMA; VIEIRA, PAULO CEZAR; VENANCIO, TIAGO; ALVES FILHO, ELENILSON DE GODOY; BATISTA, JR., JOAO M.; et al. Dimeric chalcones derivatives from Myracrodruon urundeuva act as cathepsin V inhibitors. Phytochemistry, v. 154, p. 31-38, . (15/07089-2, 06/58043-3, 14/25222-9, 09/01847-1, 13/07600-3)
BATISTA, ANDREA N. L.; DOS SANTOS, JR., FERNANDO M.; BATISTA, JR., JOAO M.; CASS, QUEZIA B.. Enantiomeric Mixtures in Natural Product Chemistry: Separation and Absolute Configuration Assignment. Molecules, v. 23, n. 2, . (15/07089-2, 16/23794-0, 14/25222-9, 13/01710-1)
SCATENA, GABRIEL S.; CASSIANO, NEILA M.; NETTO, CHAQUIP D.; COSTA, PAULO R. R.; CASS, QUEZIA B.; BATISTA, JR., JOAO M.. Preparative chiral separation and absolute configuration of the synthetic pterocarpanquinone LQB-118. Chirality, v. 29, n. 5, p. 167-171, . (15/07089-2, 14/25222-9, 13/01710-1)
SPRENGER, R. F.; THOMASI, S. S.; FERREIRA, A. G.; CASS, Q. B.; BATISTA JUNIOR, J. M.. Solution-state conformations of natural products from chiroptical spectroscopy: the case of isocorilagin. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 14, n. 13, p. 3369-3375, . (15/07089-2, 14/25222-9, 11/11021-3, 13/01710-1)
BATISTA, JR., JOAO M.; WANG, BO; CASTELLI, MARIA V.; BLANCH, EWAN W.; LOPEZ, SILVIA N.. Absolute configuration assignment of an unusual homoisoflavanone from Polygonum ferrugineum using a combination of chiroptical methods. Tetrahedron Letters, v. 56, n. 44, p. 6142-6144, . (15/07089-2, 14/25222-9)
GIMENES, LEILA; BATISTA JUNIOR, JOAO MARCOS; DOS SANTOS JUNIOR, FERNANDO MARTINS; SOUZA, MATHEUS DA SILVA; LUNA-DULCEY, LIANY; ELLENA, JAVIER ESTEVES; COMINETTI, MARCIA REGINA; DAS GRACAS FERNANDES DA SILVA, MARIA FATIMA; VIEIRA, PAULO CEZAR; FERNANDES, JOAO BATISTA; et al. Picraviane A and B: Nortriterpenes with limonoid-like skeletons containing a heptanolide E-ring system from Picramnia glazioviana. Phytochemistry, v. 163, p. 38-45, . (15/07089-2, 14/25222-9, 12/25299-6, 16/18024-1, 16/23794-0, 13/20458-1)
ORTEGA, HUMBERTO E.; BATISTA, JR., JOAO M.; MELO, WEILAN G. P.; CLARDY, JON; PUPO, MONICA T.. Absolute configurations of griseorhodins A and C. Tetrahedron Letters, v. 58, n. 50, p. 4721-4723, . (15/07089-2, 15/01001-6, 14/25222-9, 13/50954-0)
DE AMORIM, MARCELO R.; WIJERATNE, E. M. KITHSIRI; ZHOU, SHENGLIANG; ARNOLD, A. ELIZABETH; BATISTA, ANDREA N. L.; BATISTA, JOAO M.; DOS SANTOS, LOURDES C.; GUNATILAKA, A. A. LESLIE. An epigenetic modifier induces production of 3-(4-oxopyrano)-chromen-2-ones in Aspergillus sp. AST0006, an endophytic fungus of Astragalus lentiginosus. Tetrahedron, v. 76, n. 43, . (18/05905-5, 14/25222-9)
MARIACATERINA LIANZA; MARIA HELENA VERDAN; JEAN PAULO DE ANDRADE; FERRUCCIO POLI; LARISSA C. DE ALMEIDA; LETICIA V. COSTA-LOTUFO; ÁLVARO CUNHA NETO; SARAH C. C. OLIVEIRA; JAUME BASTIDA; ANDREA N. L. BATISTA; et al. Isolation, Absolute Configuration and Cytotoxic Activities of Alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae). Journal of the Brazilian Chemical Society, v. 31, n. 10, p. 2135-2145, . (14/25222-9, 15/17177-6, 14/50926-0, 18/17595-0)
PEREIRA CABRAL, MARCIA R.; CECCHETTO, MARIANA; BATISTA, JR., JOAO M.; BATISTA, ANDREA N. L.; FOGLIO, MARY ANN; TASCA GOIS RUIZ, ANA LUCIA; BARROTTO DO CARMO, MARTA R.; DA COSTA, WILLIAN FERREIRA; BALDOQUI, DEBORA C.; SARRAGIOTTO, MARIA H.. Cytotoxic sesquiterpene lactones from Campuloclinium macrocephalum (=Eupatorium macrocephalum). Phytochemistry, v. 179, . (14/25222-9)
BATISTA, ANDREA N. L.; DOS SANTOS, JR., FERNANDO M.; VALVERDE, ALESSANDRA L.; BATISTA, JR., JOAO M.. Stereochemistry of spongosoritins: beyond optical rotation. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 17, n. 45, p. 9772-9777, . (14/25222-9)
DOS SANTOS, JR., FERNANDO M.; BICALHO, KEYLLA U.; CALISTO, ITALO H.; SCATENA, GABRIEL S.; FERNANDES, JOAO B.; CASS, QUEZIA B.; BATISTA, JR., JOAO M.. Scope of the 2(5H)-furanone helicity rule: a combined ECD, VCD, and DFT investigation. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 16, n. 24, p. 4509-4516, . (15/07089-2, 14/25222-9, 13/01710-1, 12/25299-6, 10/18832-4, 16/23794-0)
LONDERO, VINICIUS S.; COSTA-SILVA, THAIS A.; ANTAR, GUILHERME M.; BAITELLO, JOAO B.; DE OLIVEIRA, LARISSA V. F.; CAMILO, FERNANDA F.; BATISTA, ANDREA N. L.; BATISTA, JR., JOAO M.; TEMPONE, ANDRE G.; LAGO, JOAO HENRIQUE G.. Antitrypanosomal Lactones from Nectandra barbellata. Journal of Natural Products, v. 84, n. 5, p. 1489-1497, . (14/25222-9, 17/17044-1, 18/10279-6, 21/02789-7, 18/07885-1)
QUEIROZ, SUZANA APARECIDA S.; PINTO, MERI EMILI F.; BOBEY, ANTONIO F.; RUSSO, HELENA M.; BATISTA, ANDREA N. L.; BATISTA, JR., JOAO M.; CODO, ANA C.; MEDEIROS, ALEXANDRA I.; BOLZANI, VANDERLAN S.. Diterpenoids with inhibitory activity of nitrite production from Croton floribundus. Journal of Ethnopharmacology, v. 249, . (19/04381-5, 13/07600-3, 14/25222-9, 17/19870-6, 17/18807-9, 14/50926-0, 17/17098-4)
ORTEGA, HUMBERTO E.; BATISTA, JR., JOAO M.; MELO, WEILAN G. P.; DE PAULA, GABRIELA T.; PUPO, MONICA T.. Structure and Absolute Configuration of Secondary Metabolites from Two Strains of Streptomyces chartreusis Associated with Attine Ants. Journal of the Brazilian Chemical Society, v. 30, n. 12, SI, p. 2672-2680, . (15/07089-2, 13/50954-0, 14/25222-9, 14/14095-6, 17/05920-1, 15/01001-6)
CCANA-CCAPATINTA, GARI V.; SAMPAIO, BRUNO L.; DOS SANTOS, JR., FERNANDO M.; BATISTA, JR., JOAO M.; DA COSTA, FERNANDO B.. Absolute configuration assignment of caffeic acid ester derivatives from Tithonia diversifolia by vibrational circular dichroism: the pitfalls of deuteration. TETRAHEDRON-ASYMMETRY, v. 28, n. 12, p. 1823-1828, . (15/07089-2, 14/25222-9, 11/13361-6, 16/23794-0, 14/16850-6, 14/26866-7)
GUBIANI, JULIANA R.; OLIVEIRA, MICHELE C. S.; NEPONUCENO, RICARDO A. R.; CAMARGO, MARIA J.; GARCEZ, WALMIR S.; BIZ, ANDRESSA R.; SOARES, MARCOS A.; ARAUJO, ANGELA R.; BOLZANI, VANDERLAN DA S.; LISBOA, HELEN C. F.; et al. Cytotoxic prenylated indole alkaloid produced by the endophytic fungus Aspergillus terreus P63. PHYTOCHEMISTRY LETTERS, v. 32, p. 162-167, . (13/50228-8, 14/25222-9)
DE AMORIM, MARCELO R.; HILARIO, FELIPE; DOS SANTOS JUNIOR, FERNANDO M.; BATISTA JUNIOR, JOAOM.; BAUAB, TAIS M.; ARAUJO, ANGELA R.; CARLOS, IRACILDA Z.; VILEGAS, WAGNER; DOS SANTOS, LOURDES C.. New Benzaldehyde and Benzopyran Compounds from the Endophytic Fungus Paraphaeosphaeria sp. F03 and Their Antimicrobial and Cytotoxic Activities {*}. Planta Medica, v. 85, n. 11/12, p. 957-964, . (14/25222-9, 16/23794-0, 15/04899-3, 15/11058-5)
CALDAS, LHAIS ARAUJO; RODRIGUES, MARIANA T.; BATISTA, ANDREA N. L.; BATISTA, JR., JOAO M.; LAGO, JOAO H. G.; FERREIRA, MARCELO J. P.; RUBIO, ILEANA G. S.; SARTORELLI, PATRICIA. Sesquiterpene Lactones from Calea pinnatifida: Absolute Configuration and Structural Requirements for Antitumor Activity. Molecules, v. 25, n. 13, . (16/24985-4, 14/25222-9)
PASSARELI, F.; BATISTA, A. N. L.; CAVALHEIRO, A. J.; HERREBOUT, W. A.; BATISTA JUNIOR, J. M.. Vibrational spectroscopy as a direct stereochemical probe for polyhydroxylated molecules. Physical Chemistry Chemical Physics, v. 18, n. 45, p. 30903-30906, . (15/07089-2, 14/25222-9)
BATISTA, ANDREA N. L.; DOS SANTOS-PINTO, JOSE ROBERTO A.; BATISTA, JR., JOAO M.; SOUZA-MOREIRA, TATIANA M.; SANTONI, MARIANA M.; ZANELLI, CLESLEI F.; KATO, MASSUO J.; LOPEZ, SILVIA N.; PALMA, MARIO S.; FURLAN, MAYSA. The Combined Use of Proteomics and Transcriptomics Reveals a Complex Secondary Metabolite Network in Peperomia obtusifolia. Journal of Natural Products, v. 80, n. 5, p. 1275-1286, . (11/51684-1, 13/07600-3, 14/25222-9, 11/01003-8)
CANZI, EDIONE F.; DOS SANTOS, JR., FERNANDO M.; MENEGHETTI, EMANUELLE K.; SALES MAIA, BEATRIZ HELENA L. N.; BATISTA, JR., JOAO M.. Absolute configuration of a rare dibenzoylmethane derivative from Dahlstedtia glaziovii (Fabaceae). Tetrahedron Letters, v. 59, n. 2, p. 135-137, . (15/07089-2, 16/23794-0, 14/25222-9)
BATISTA, JR., JOAO M.; BLANCH, EWAN W.; BOLZANI, VANDERLAN DA SILVA. Recent advances in the use of vibrational chiroptical spectroscopic methods for stereochemical characterization of natural products. NATURAL PRODUCT REPORTS, v. 32, n. 9, p. 1280-1302, . (13/07600-3, 14/50304-9, 14/25222-9, 11/22339-4)
BERNARDINO, K.; PINTO, M. E. F.; BOLZANI, V. S.; DE MOURA, A. F.; BATISTA JUNIOR, J. M.. Pinpointing disulfide connectivities in cysteine-rich proteins. CHEMICAL COMMUNICATIONS, v. 53, n. 53, p. 7337-7340, . (15/07089-2, 12/15147-4, 14/50304-9, 14/25222-9, 13/07296-2, 13/07600-3)

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