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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats

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Author(s):
Fernandes Scappaticci, Renan Aparecido [1] ; Berretta, Andresa Aparecida [2] ; Torres, Elina Cassia [2] ; Moreira Buszinski, Andrei Felipe [2] ; Fernandes, Gabriela Lopes [1] ; dos Reis, Thaila Fernanda [1] ; de Souza-Neto, Francisco Nunes [3] ; Gorup, Luiz Fernando [3] ; de Camargo, Emerson Rodrigues [3] ; Barbosa, Debora Barros [1]
Total Authors: 10
Affiliation:
[1] Sao Paulo State Univ UNESP, Dept Dent Mat & Prosthodont, Sch Dent, BR-16015050 Aracatuba, SP - Brazil
[2] Apis Flora Ind & Comercial Ltda, Lab Res Dev & Innovat, BR-14020670 Ribeirao Preto, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ANTIBIOTICS-BASEL; v. 10, n. 11 NOV 2021.
Web of Science Citations: 0
Abstract

Infected cutaneous ulcers from diabetic rats with Candida albicans and Streptococcus aureus were treated with spray formulations containing green silver nanoparticles (GS), chemical silver nanoparticles (CS), or pomegranate peel extract (PS). After wound development and infection, the treatments were performed twice per day for 14 days. The wound healing was analyzed on days 2, 7, and 14 through the determination of CFUs, inflammatory infiltrate, angiogenesis, fibroplasia, myeloperoxidase, and collagen determination. Expressive improvement in wound healing was noted using both silver nanoparticles for 7 days. All the treatments were superior to controls and promoted significant S. aureus reduction after 14 days. CS presented better anti-inflammatory results, and GS and CS the highest number of fibroblasts. Despite the techniques' limitations, GS and CS demonstrated considerable potential for managing infected wounds, especially considering no early strategies prior to the drugs, such as the debridement of these wounds, were included. (AU)

FAPESP's process: 16/04230-9 - Extract obtaining and synthesis of silver nanoparticles from Punica granatum (pomegranate): Physico-chemical characterization, determination of antimicrobial activity and potential healing
Grantee:Renan Aparecido Fernandes
Support Opportunities: Scholarships in Brazil - Doctorate