| Full text | |
| Author(s): Show less - |
Batista, Alexandre Mendes
[1]
;
Caetano, Matheus W.
[2, 1]
;
Stincarelli, Maria A.
[3]
;
Mamana, Ana C.
[1]
;
Zerbinati, Rodrigo Melim
[1]
;
Sarmento, Dmitry J. S.
[2, 4]
;
Gallottini, Marina
[2]
;
Caixeta, V, Rafael A.
;
Medina-Pestana, Jose
[5]
;
Hasseus, Bengt
[6]
;
Zanella, Louise
[7]
;
Tozetto-Mendoza, Tania R.
[1]
;
Giannecchini, Simone
[3]
;
Braz-Silva, Paulo H.
[1, 8]
Total Authors: 14
|
| Affiliation: | [1] Univ Sao Paulo, Sch Med, Inst Trop Med Sao Paulo, Lab Virol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo - Brazil
[3] Univ Florence, Dept Expt & Clin Med, Viale Morgagni 48, I-50134 Florence - Italy
[4] State Univ Paraiba, Dept Oral Med, Araruna - Brazil
[5] Univ Fed Sao Paulo, Sch Med, Kidney & Hypertens Hosp, Div Renal Transplantat, Sao Paulo - Brazil
[6] Univ Gothenburg, Inst Odontol, Dept Oral Med & Pathol, Gothenburg - Sweden
[7] Univ La Frontera, Lab Integrat Biol LIBi, Sci & Technol Bioresource Nucleus Ctr Excellence, Temuco - Chile
[8] Caixeta, Rafael A., V, Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo - Brazil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | JOURNAL OF ORAL MICROBIOLOGY; v. 14, n. 1 JAN 1 2022. |
| Web of Science Citations: | 0 |
| Abstract | |
Background Several reports have proposed that the viral load of torque teno virus (TTV) in plasma is a biomarker of immune function in solid organ transplantation (SOT) and in allogeneic hematopoietic stem cell transplantation. Additionally, for the latter one, TTV-DNA quantification in saliva has also been suggested. Aim to investigate the correlation between the TTV viral load and immune function in paired saliva and plasma samples in patients on kidney transplantation. Materials and Methods TTV-DNA viral load was quantified in paired samples of saliva and plasma from 71 patients before and a short-time after renal-transplantation by real-time PCR. Results The data obtained from 213 paired samples showed a slight consistency in the comparison between saliva and plasma, with prevalence of TTV-DNA being 58%, 52% and 60% in saliva samples and 60%, 73% and 90% in plasma samples before and at 15-20 and 45-60 days after transplantation, respectively. Additionally, a high TTV viral load was observed in plasma at 15-20 and 45-60 days after transplantation compared to that observed in saliva at the same time. Conclusions Overall, monitoring TTV-DNA in saliva samples could be an additional fast non-invasive option to assess the immune functionality in SOT populations. (AU) | |
| FAPESP's process: | 21/03563-2 - Oral shedding and viremia of torque teno virus (TTV) in renal transplant recipients |
| Grantee: | Matheus Willian Caetano |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 17/07778-8 - Impact of renal transplantation on oral health and dental management |
| Grantee: | Marina Helena Cury Gallottini |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/07727-9 - Evaluation of immunoregulatory microenvironment of oral premalignant lesions, squamous cell carcinomas and oropharyngeal carcinomas related to HPV or not. |
| Grantee: | Paulo Henrique Braz da Silva |
| Support Opportunities: | Regular Research Grants |