High-intensity interval training attenuates the effects caused by arterial hypertension in the ventral prostate

Author(s)

Correia, Rafael Ribeiro ^[1] ; Garcia Batista, Victor Rogerio ^[1] ; Cruz Veras, Allice Santos ^{[1, 2]} ; de Almeida Tavares, Maria Eduarda ^{[1, 2]} ; Agostinho Souza, Francilene Lima ^[3] ; Pacagnelli, Francis Lopes ^[3] ; Salome Campos, Dijon Henrique ^[4] ; Giometti, Ines Cristina ^[5] ; Teixeira, Giovana Rampazzo ^{[1, 2]}

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Technol & Sci, Dept Phys Educ, Expt Lab Exercise Biol LEBioEx, Sao Paulo - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Dent Aracatuba, Multicentr Program Postgrad Physiol Sci, Aracatuba, SP - Brazil

^[3] Univ Western Sao Paulo UNOESTE, Postgrad Anim Sci Program, Presidente Prudente, SP - Brazil

^[4] Sao Paulo State Univ, Botucatu Med Sch, Dept Clin Med, Botucatu, SP - Brazil

^[5] Univ Western Sao Paulo UNOESTE, Fac Agr Sci, Dept Reprod, Presidente Prudente, SP - Brazil

• Document type: Journal article
• Source: PROSTATE; v. 82, n. 3 DEC 2021.
• Web of Science Citations: 0

Abstract

Background The prostatic effects induced by arterial hypertension is very controversial and its mechanism is unclear. High-intensity interval training (HIIT) is an exercise considered to be hypotensive. The objective of this work was to investigate the molecular, biochemical, and morphological effects of 8 weeks of HIIT in the prostatic tissue of spontaneously hypertensive rats (SHR). Methods Twenty male SHR rats, 51.4 weeks old, were used. The SHR animals were divided into two groups: spontaneously sedentary hypertensive and spontaneously hypertensive submitted to HIIT. We analyze androgens receptor and glucocorticoid receptors in the prostate. Still, we verify effects of the hypertension and HIIT on the physiopathology prostatic, for immunohistochemistry investigated BCL-2, BAX, IGF-1, FAS/CD95, data's inflammatory tumour necrosis factor alpha, nuclear factor kappa B and interleukin (IL)-6, anti-inflammatory IL-10. The echocardiographic evaluation was performed at the baseline and after the training period. Results Arterial hypertension promote high prostatic intraepithelial neoplasia incidence in the prostate, increases IGF-1, BCL-2 (p < 0.05), and inflammatory proteins (p < 0.05). Eight weeks of HIIT training reduced the arterial pressure and increase the concentration of tissue collagen and intracellular glycogen and showed a higher expression of BAX, FAS/CD95, and IL-10 proteins (p < 0.05), coinciding with a lower incidence of lesions and lower prostate weight (p < 0.05) and reduction of the BCL-2 and IGF-1. Conclusion Our data suggested that arterial hypertension suppressed apoptosis and increased damage prostatic. On other hand, HIIT promotes morphology and function improves in the prostatic environment, inhibited inflammation, and increased apoptosis. (AU)

• FAPESP's process: 18/22682-0 - Effects of high intensity interval training on the reproductive parameters of spontaneously hypertensive rats
• Grantee: Ines Cristina Giometti Ceda
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/11924-5 - Effects of high intensity interval physical training (HIIT) on the histological and molecular parameters of the spontaneously hypertensive rat (SHR)
• Grantee: Rafael Ribeiro Correia
• Support Opportunities: Scholarships in Brazil - Scientific Initiation