Effects of high intensity interval training on the reproductive parameters of spontaneously hypertensive rats

• Grant number: 18/22682-0
• Support Opportunities: Regular Research Grants
• Duration: May 01, 2019 - October 31, 2021
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Ines Cristina Giometti Ceda
• Grantee: Ines Cristina Giometti Ceda
• Host Institution: Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade do Oeste Paulista (UNOESTE). Presidente Prudente , SP, Brazil
• Associated researchers: Ana Paula Alves Favareto ; Caliê Castilho ; Francis Lopes Pacagnelli ; Giovana Rampazzo Teixeira ; Leonardo de Oliveira Mendes

Abstract

The present project reflects the importance of investigating the effects of high intensity interval training (HIIT) on reproductive parameters and whether HIIT should be indicated for hypertensive individuals. Therefore, the objective of this study is to verify the alterations in endocrine, testicular, and spermatic reproductive parameters, as well as to investigate and quantify the genic and proteinic expression of genes linked to angiogenesis (Vegf, Kdr, Flt1, and Hif1) in the testicles of spontaneously hypertensive rats (SHR) submitted to HIIT. For this, biological materials will be collected from Wistar-Kyoto rats, male, adult, with and without spontaneous hypertension. Half of the SHR will be submitted to HIIT, according to the chosen protocol. The testicles will be used for histological and molecular analyzes (RT-qPCR and Western Blotting); the spermatozoa of the vas deferens for motility and spermatic pathology; and the blood plasma for hormonal dosage. The results will be analyzed for the normality assumption using the Shapiro-Wilk test. Variables with parametric distribution will be submitted to analysis of variance (ANOVA) to compare the means of the three groups, followed by the Tukey test, and for non-parametric variables, the Kruskal-Wallis test followed by Dunn's test. Differences will be considered when p <0.05. The scientific hypothesis of the present study is that hypertension will alter spermatogenesis and that HIIT will modulate the negative effects of hypertension and may be indicated for hypertensive individuals. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CORREIA, RAFAEL RIBEIRO; GARCIA BATISTA, VICTOR ROGERIO; CRUZ VERAS, ALLICE SANTOS; DE ALMEIDA TAVARES, MARIA EDUARDA; AGOSTINHO SOUZA, FRANCILENE LIMA; PACAGNELLI, FRANCIS LOPES; SALOME CAMPOS, DIJON HENRIQUE; GIOMETTI, INES CRISTINA; TEIXEIRA, GIOVANA RAMPAZZO. High-intensity interval training attenuates the effects caused by arterial hypertension in the ventral prostate. PROSTATE, v. 82, n. 3, DEC 2021. (18/22682-0, 19/11924-5)