Effects of high intensity interval physical training (HIIT) on the histological and molecular parameters of the spontaneously hypertensive rat (SHR)

• Grant number: 19/11924-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): August 01, 2019
• Effective date (End): July 31, 2021
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Giovana Rampazzo Teixeira
• Grantee: Rafael Ribeiro Correia
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

The prostate is a sexual gland of the male genital system that plays an important role in the reproductive process. Several biological processes such as cell proliferation and differentiation, secretion and tumor growth are regulated and influenced by different factors. Hypertension is a very recurrent disease in the world population, affecting large numbers of people, especially the elderly population. Arterial hypertension is mainly related to lifestyle habits and insufficient physical activity. Experimental studies in animals use spontaneously hypertensive rats, because they present changes in the urinary tract and in the prostatic medium very similar to humans. In contrast, what is also being investigated are the adaptations promoted by physical exercise in the prostatic environment. With this, physical exercise emerges as an alternative to attenuate the effects of hypertension in the prostatic environment. Some studies already show the analogy between the practice of physical exercise promoting alterations in the cellular metabolism, also influencing the prostatic environment. Based on these premises the objective since work is to investigate the influence of arterial hypertension and physical training of high intensity in the prostate of SHR rats. We will use 26 rats divided into three groups: SHRc, SHR+T and WKy. The immunohistochemical parameters of the AR and IGF-1 proteins, immunohistochemistry of the inflammatory route (TNF-±, NF-kB, IL-6, IL-10, Bax and Bcl-2), cell cycle proteins .

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CORREIA, RAFAEL RIBEIRO; GARCIA BATISTA, VICTOR ROGERIO; CRUZ VERAS, ALLICE SANTOS; DE ALMEIDA TAVARES, MARIA EDUARDA; AGOSTINHO SOUZA, FRANCILENE LIMA; PACAGNELLI, FRANCIS LOPES; SALOME CAMPOS, DIJON HENRIQUE; GIOMETTI, INES CRISTINA; TEIXEIRA, GIOVANA RAMPAZZO. High-intensity interval training attenuates the effects caused by arterial hypertension in the ventral prostate. PROSTATE, v. 82, n. 3, DEC 2021. (18/22682-0, 19/11924-5)