Boron in Medicinal and Organic Chemistry

Author(s)

Bruno Prates, Joao Lucas ^{[1, 2]} ; Pavan, Aline Renata ^{[1, 2]} ; dos Santos, Jean Leandro ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Inst Chem, Araraquara, SP - Brazil

• Document type: Review article
• Source: CURRENT ORGANIC CHEMISTRY; v. 25, n. 16, p. 1853-1867, 2021.
• Web of Science Citations: 0

Abstract

Nowadays, boron-containing compounds have gained researchers' attention be-cause of the wide versatility and applicability of this element in both organic and medicinal chemistry. Since its discovery, its use in medicinal chemistry was neglected because of its possible toxic effects. However, in the past years, boron-containing compounds did not show such effects, and some drugs have already been approved by the Food and Drug Administra-tion to treat diseases, including cancer, infections, and inflammation. Several boron-containing compounds are used in organic and medicinal chemistry, either as a reagent or therapeutic agent. The chemical properties of this element make its use possible in organic synthesis as a reducing agent and catalyst, mainly in cross-coupling reactions. Among boron-containing compounds, boranes, azaborines, benzoxaborole, boronic acid, and boron deriva-tives are most commonly described. This review article discusses the main properties of boron-containing com-pounds, their preparation by organic synthesis, as well as their applications in organic synthesis and medicinal chem-istry fields, developing new perspectives for further investigations. (AU)

• FAPESP's process: 18/11079-0 - Synthesis and antitubercular activity of new N-oxide compounds designed to treat multiresistant-tuberculosis
• Grantee: Jean Leandro dos Santos
• Support Opportunities: Regular Research Grants