Studies aiming at the enantioselective oxidative Heck reaction

• Grant number: 16/21487-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): November 01, 2016
• Effective date (End): October 31, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Carlos Roque Duarte Correia
• Grantee: Tomaz Henrique Duarte Chorro
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 14/25770-6 - New frontiers in cross-coupling reactions promoted by palladium: combining enantioselective catalysis, C-H activations, new materials and in flux reactions aiming at high efficiency and sustainability in synthetic processes, AP.TEM

Abstract

This project aims at the study and development of reactional conditions to achieve effective enantioselective oxidative Heck reactions under optimized conditions. We will evaluate the performance of several solvents, paladium sources, chiral ligands and oxidizing agents. The expectation is that we can generate a large library of compounds from diverse boronic acids to synthesize advanced intermediates containing multiple functional groups which should allow the synthesis of compounds with synthetic and medicinal value. (AU)