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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A Naked Eye-Invisible Ratiometric Fluorescent Microneedle Tattoo for Real-Time Monitoring of Inflammatory Skin Conditions

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Author(s):
Babity, Samuel [1] ; Couture, Frederic [2, 3, 4] ; Campos, Estefania V. R. [5, 6] ; Hedtrich, Sarah [6] ; Hagen, Raphael [7] ; Fehr, Daniel [7] ; Bonmarin, Mathias [7] ; Brambilla, Davide [1]
Total Authors: 8
Affiliation:
[1] Univ Montreal, Fac Pharm, CP 6128, Succursale Ctr ville, Montreal, PQ H3C 3J7 - Canada
[2] TransBIOTech, 201 Monseigneur Bourget Levis, Quebec City, PQ G6V 6Z9 - Canada
[3] Univ Laval, Nutraceuticals & Funct Foods Inst INAF, Quebec City, PQ G1K 7P4 - Canada
[4] Ctr Integre Sante & Serv Sociaux Chaudiere Appala, Quebec City, PQ - Canada
[5] Fed Univ ABC, Human & Nat Sci Ctr, BR-09210580 Santo Andre, SP - Brazil
[6] Univ British Columbia, Fac Pharmaceut Sci, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3 - Canada
[7] Zurich Univ Appl Sci, Sch Engn, Technikumstr 9, CH-8400 Winterthur - Switzerland
Total Affiliations: 7
Document type: Journal article
Source: ADVANCED HEALTHCARE MATERIALS; DEC 2021.
Web of Science Citations: 0
Abstract

The field of portable healthcare monitoring devices has an urgent need for the development of real-time, noninvasive sensing and detection methods for various physiological analytes. Currently, transdermal sensing techniques are severely limited in scope (i.e., measurement of heart rate or sweat composition), or else tend to be invasive, often needing to be performed in a clinical setting. This study proposes a minimally invasive alternative strategy, consisting of using dissolving polymeric microneedles to deliver naked eye-invisible functional fluorescent ratiometric microneedle tattoos directly to the skin for real-time monitoring and quantification of physiological and pathological parameters. Reactive oxygen species are overexpressed in the skin in association with various pathological conditions. Here, one demonstrates for the first time the microneedle-based delivery to the skin of active fluorescent sensors in the form of an invisible, ratiometric microneedle tattoo capable of sensing reactive oxygen species in a reconstructed human-based skin disease model, as well as an in vivo model of UV-induced dermal inflammation. One also elaborates a universal ratiometric quantification concept coupled with a custom-built, multiwavelength portable fluorescence detection system. Fully realized, this approach presents an opportunity for the minimally invasive monitoring of a broad range of physiological parameters through the skin. (AU)

FAPESP's process: 17/24402-1 - pH AND TEMPERATURE SENSITIVE DRUG NANOCARRIERS FOR SKIN APPLICATIONS
Grantee:Estefânia Vangelie Ramos Campos
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 19/05100-0 - Evaluation of the biological activity of topical formulations of budesonide in inflammatory skin models
Grantee:Estefânia Vangelie Ramos Campos
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor