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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impact of intravesical instillation of a novel biological response modifier (P-MAPA) on progress of non-muscle invasive bladder cancer treatment in a rat model

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Author(s):
Favaro, Wagner J. [1] ; Socca, Eduardo A. R. [1] ; Bockelmann, Petra K. [1] ; Reis, Ianny B. [1] ; Garcia, V, Patrick ; Duran, Nelson [2, 3]
Total Authors: 6
Affiliation:
[1] Univ Campinas UNICAMP, Dept Struct & Funct Biol, Lab Urogenital Carcinogenesis & Immunotherapy, Ave Bertrand Russell S-N, BR-13083865 Campinas, SP - Brazil
[2] Fed Univ ABC UFABC, Nanomed Res Unit NANOMED, Santo Andre, SP - Brazil
[3] Garcia, Patrick, V, Univ Campinas UNICAMP, Dept Struct & Funct Biol, Lab Urogenital Carcinogenesis & Immunotherapy, Ave Bertrand Russell S-N, BR-13083865 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: MEDICAL ONCOLOGY; v. 39, n. 2 FEB 2022.
Web of Science Citations: 0
Abstract

This work describes the effects of immunotherapy with Protein Aggregate Magnesium-Ammonium Phospholinoleate-Palmitoleate Anhydride in the treatment of non-muscle invasive bladder cancer in an animal model. NMIBC was induced by treating female Fischer 344 rats with N-methyl-N-nitrosourea. After treatment with MNU, the rats were distributed into four experimental groups: Control (without MNU) group, MNU (cancer) group, MNU-BCG (Bacillus Calmette-Guerin) group, and MNU-P-MAPA group. P-MAPA intravesical treatment was more effective in histopathological recovery from cancer state in relation to BCG treatment. Western blot assays showed an increase in the protein levels of c-Myc, COUP-TFII, and wild-type p53 in P-MAPA-treated rats in relation to BCG-treated rats. In addition, rats treated with P-MAPA intravesical immunotherapy showed the highest BAX protein levels and the lowest proliferation/apoptotic ratio in relation to BCG-treated rats, pointing out a preponderance of apoptosis. P-MAPA intravesical treatment increased the wild-type p53 levels and enhanced c-Myc/COUP-TFII-induced apoptosis mediated by p53. These alterations were fundamental for histopathological recovery from cancer and for suppress abnormal cell proliferation. This action of P-MAPA on apoptotic pathways may represent a new strategy for treating NMIBC. (AU)

FAPESP's process: 14/11866-1 - Mechanisms and effects of the immunomodulator P-MAPA in the treatment of prostate cancer and non-muscle invasive bladder cancer: interfaces between energy metabolism, oxidative balance, angiogenesis and signaling pathway of toll-like receptors
Grantee:Petra Karla Böckelmann
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/13585-4 - EFFECTS OF INTRAVESICAL IMMUNOTHERAPIES WITH BCG AND P-MAPA ON SEXUAL STEROID HORMONES RECEPTORS AND REACTIVE OXYGEN SPECIES: POTENTIAL THERAPEUTIC STRATEGIES FOR URINARY BLADDER CANCER
Grantee:Patrick Vianna Garcia
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/05726-4 - Oxidative Stress, Antioxidant Enzyme Activities and Toll-Like Receptors 2 and 4 Signaling Pathway in Urinary Bladder Cancer Progression of Rats Submitted to Bacillus Calmette-Guerin and P-MAPA Intravesical Immunotherapies.
Grantee:Fábio Rodrigues Ferreira Seiva
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/20706-2 - New therapeutic strategies for non-muscle invasive bladder cancer: effects of BCG and P-mapa immunotherapies on the steroid hormone receptors and reactive oxygen species
Grantee:Wagner José Fávaro
Support type: Regular Research Grants