| Full text | |
| Author(s): Show less - |
Araujo, Tamara Teodoro
[1]
;
Camiloti, Gabriel Domingues
[1]
;
Valle, Aline Dionizio
[1]
;
Silva, Natara Dias Gomes
[1]
;
Souza, Beatriz Martines
[1]
;
Carvalho, Thamyris de Souza
[1]
;
Camara, Joao Victor Frazao
[1]
;
Shibao, Priscila Yumi Tanaka
[2]
;
Henrique-Silva, Flavio
[2]
;
Cruvinel, Thiago
[1]
;
Magalhaes, Ana Carolina
[1]
;
Buzalaf, Marilia Afonso Rabelo
[1]
Total Authors: 12
|
| Affiliation: | [1] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Genet & Evolut, Lab Mol Biol, Sao Carlos - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | BIOFOULING; v. 37, n. 1, p. 109-116, JAN 28 2021. |
| Web of Science Citations: | 2 |
| Abstract | |
The antimicrobial and anticaries effects of CaneCPI-5 were evaluated. Ninety bovine enamel samples were treated for 60 s with either phosphate-buffered-saline (PBS), 0.12% chlorhexidine (CHX), 0.05 mg ml(-1) CaneCPI-5, 0.1 mg ml(-1) CaneCPI-5 or 0.5 mg ml(-1) CaneCPI-5. They were incubated with inoculum (human saliva + McBain's saliva) for the first 8 h. From then until the end of the experiment, the enamel was exposed to McBain saliva with sucrose and, once a day, for 5 days, they were treated with the solutions. At the end of the experimental period, resazurin and viable plate count assays were performed. Enamel demineralization was also measured. All concentrations of CaneCPI-5 and CHX significantly reduced the activity of biofilms compared with PBS. For viable plate counts, all treatments similarly reduced the lactobacilli and total streptococci; for the mutans streptococci, 0.05 mg ml(-1) CaneCPI-5 performed better than CHX. All CaneCPI-5 concentrations significantly reduced the integrated mineral loss. This study represents the first step regarding the use of CaneCPI-5 within the concept of acquired enamel pellicle and biofilm engineering to prevent dental caries. (AU) | |
| FAPESP's process: | 19/26070-1 - Modulation of acquired enamel pellicle to control dental mineral loss: unravelling mechanisms to make therapies possible |
| Grantee: | Marília Afonso Rabelo Buzalaf |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/08032-5 - Acquired pellicle engineering for protection against caries and tooth erosion: effect of cystatin, statherin and hemoglobin on the proteomic profile of the acquired pellicle, bacterial biofilm and dental enamel |
| Grantee: | Tamara Teodoro Araujo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |