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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ultilayered solid phase extraction and ultra performance liquid chromatographic method for suspect screening of halogenated pharmaceuticals and photo-transformation products in freshwater - comparison between data-dependent and data-independent acquisition mass spectrometr

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Author(s):
Fagnani, Enelton [1, 2] ; Montemurro, Nicola [2] ; Perez, Sandra [2]
Total Authors: 3
Affiliation:
[1] Univ Campinas FT UNICAMP, Res Grp Optimizat Analyt Technol Appl Environm &, Sch Technol, Rua Paschoal Marmo 1888, BR-13484332 Limeira, SP - Brazil
[2] Inst Environm Assessment & Water Res Spanish Coun, Water Environm & Food Chem Res Grp ENFOCHEM, Dept Environm Chem, CSIC, Barcelona - Spain
Total Affiliations: 2
Document type: Journal article
Source: Journal of Chromatography A; v. 1663, JAN 25 2022.
Web of Science Citations: 0
Abstract

Since conventional biological wastewater treatments are not admittedly effective to convert pharmaceutical active compounds (PhACs) into nontoxic products, natural abiotic mechanisms such as solar photolysis arises as an important degradation process, especially for halogenated molecules. In the present work, photolysis simulation was carried out in-lab for precursors and their respective photo-transformation products (photo-TPs), which were analyzed through reversed-phase ultra-high performance liquid chromatography coupled to high resolution mass spectrometry (RP-UHPLC-HRMS). An in-house library was created in order to provide reference information for target (precursors) and suspect screening (photo-TPs) analysis of freshwater samples from impacted aquatic environments. Strategies in the use of data-dependent acquisition (DDA) and data-independent acquisition (DIA), as well as the data processing software are discussed here for the identification of 6 PhACs and photo-TPs. Because no standards of photo-TPs were available, only the target compounds, i.e. sitagliptin (398 +/- 2 ng L-1), iohexol (209 +/- 5 ng L-1), lamotrigine (103 +/- 10 ng L-1), losartan (43 +/- 10 ng L-1), ofloxacin (28 +/- 7 ng L-1), and sertraline (25 +/- 7 ng L-1) could be quantified through multiple standard additions. (C) 2021 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 18/09875-3 - Detection of halogenated pharmaceuticals and their transformation products in freshwater ecosystem by liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) using suspect screening approach
Grantee:Enelton Fagnani
Support Opportunities: Scholarships abroad - Research