| Full text | |
| Author(s): |
Total Authors: 3
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| Affiliation: | [1] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Lab Immunometab, Campinas - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Post Grad Program Immunol, Sao Paulo - Brazil
[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Boston, MA 02115 - USA
[4] Univ Estadual Campinas, Expt Med Res Cluster EMRC, Campinas - Brazil
[5] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas - Brazil
Total Affiliations: 5
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| Document type: | Journal article |
| Source: | Antioxidants & Redox Signaling; JAN 2022. |
| Web of Science Citations: | 0 |
| Abstract | |
Significance: Immunometabolic regulation of macrophages is a growing area of research across many fields. Here, we review the contribution of solute carriers (SLCs) in regulating macrophage metabolism. We also highlight key mechanisms that regulate SLC function, their effects on mitochondrial activity, and how these intracellular activities contribute to macrophage fitness in health and disease.Recent Advances: SLCs serve as a major drug absorption pathway and represent a novel category of therapeutic drug targets. SLC dynamics affect cellular nutritional sensors, such as AMP-activated protein kinase and mammalian target of rapamycin, and consequently alter the cellular metabolism and mitochondrial dynamics within macrophages to adapt to a new functional phenotype.Critical Issues: SLC function affects macrophage phenotype, but their mechanisms of action and how their functions contribute to host health remain incompletely defined.Future Directions: Few studies focus on the impact of solute transporters on macrophage function. Identifying which SLCs are present in macrophages and determining their functional roles may reveal novel therapeutic targets with which to treat metabolic and inflammatory diseases. (AU) | |
| FAPESP's process: | 13/07607-8 - OCRC - Obesity and Comorbidities Research Center |
| Grantee: | Licio Augusto Velloso |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 19/19435-3 - The role of DNA damage and mitochondrial function in vascular, immune and neurological ageing (DNA MoVINg) |
| Grantee: | Carlos Frederico Martins Menck |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/25973-8 - Mitoimmunity: mitochondria adaptation in pathological and physiological states |
| Grantee: | Pedro Manoel Mendes de Moraes Vieira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/15626-8 - Macrophages and T lymphocytes immunometabolism in metabolic and inflammatory diseases |
| Grantee: | Pedro Manoel Mendes de Moraes Vieira |
| Support Opportunities: | Research Grants - Young Investigators Grants |