Thermal study and characterization of new cocrystals of ciprofloxacin with picolinic acid

Author(s)

Torquetti, Carolina ^[1] ; Ferreira, Patricia Osorio ^[1] ; de Almeida, Amanda Cosmo ^[1] ; Fernandes, Richard Perosa ^[2] ; Caires, Flavio Junior ^{[1, 2]}

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Sci, Chem Dept, Bauru, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Inst Chem, Postgrad Program Chem, Araraquara, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY; v. 147, n. 2, p. 1299-1306, JAN 2022.
• Web of Science Citations: 0

Abstract

This article describes the mechanochemical synthesis (liquid-assisted grinding (LAG) and neat grinding (NG)), characterization and thermoanalytical study of new cocrystals of ciprofloxacin (CIP) with picolinic acid (PCA) in a 1:1 molar ratio. Characterization was performed through thermoanalytical techniques (differential scanning calorimetry (DSC), simultaneous thermogravimetry and differential scanning calorimetry (TG-DSC)), X-ray powder diffraction (XRPD) and infrared spectroscopy (IR). The thermoanalytical study, together with the XRPD and IR techniques, confirmed the formation of new cocrystal and helped to understand its formation. From the LAG method, using ethanol as a solvent, a cocrystal solvate was obtained. The NG method, together with thermal stress, favored obtaining the cocrystal through a coamorphous intermediate phase. Solubility study of all new materials showed an increase in CIP concentration for the cocrystals compared to pure drug. (AU)

• FAPESP's process: 18/24378-6 - Synthesis, characterization and thermoanalytical study of Valsartan, Candesartan Cilexetil and Olmesartan medoxomil co-crystals
• Grantee: Flávio Junior Caires
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/14936-9 - Preparation, characterization and thermoanalytical studies of heterogeneous catalysts of double selenates of Mg/Co and Mg/Cu in biodiesel production using different oils
• Grantee: Massao Ionashiro
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/09022-7 - Thermoanalytical studies, synthesis and characterization of the solid co-crystals of antibiotics (fluoroquinolones) with some co-formers
• Grantee: Massao Ionashiro
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/19863-4 - Thermoanalytical studies, synthesis and characterization of the solid co-crystals of ciprofloxacin with some co-formers
• Grantee: Carolina Torquetti
• Support Opportunities: Scholarships in Brazil - Scientific Initiation