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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Investigation of a modified hydraulic calcium silicate-based material - Bio-C Pulpo

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Pelepenko, Lauter Eston [1] ; Saavedra, Flavia [1] ; Marconato Antunes, Thiago Bessa [1] ; Bombarda, Gabriela Fernanda [1] ; Figueiredo de Almeida Gomes, Brenda Paula [1] ; Zaia, Alexandre Augusto [1] ; Marciano, Marina Angelica [1]
Total Authors: 7
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Restorat Dent, UNICAMP, Piracicaba, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Brazilian Oral Research; v. 35, 2021.
Web of Science Citations: 1

This study evaluated the physicochemical, biological, and antimicrobial properties of a new hydraulic calcium silicate-based modified material, and compared it with MTA Repair HP and MTA Angelus. The materials were assessed regarding color luminosity (L), color change, radiopacity, setting time, and ISO 6876:2012 linear flow. Volumetric filling and volume change were evaluated using microcomputed-tomography (mu CT). Chemical characterization after 28 days in Hank's Balanced Salt Solution (HBSS) and pH analysis were also assessed. Biological characterization of cytotoxicity and microbiological assessment were also undertaken. Shapiro-Wilk, ANOVA, Levene and post hoc analyses with Bonferroni correction were performed, adopting a 5% significance level (p <0.05). Bio-C Pulpo exhibited the highest L values after 90 days. All tested materials demonstrated color change during the analyses, and had radiopacity above 5 mm Al. MTA Repair HP set faster than Bio-C Pulpo, whereas the latter had the highest linear flow. MTA Repair HP had the highest volumetric filling in mu CT analysis. Bio-C Pulpo showed the highest alkalinity during all tested periods, and the highest volumetric loss (above 9%), in comparison with MTA Repair HP and MTA Angelus. Bio-C Pulpo did not form calcium hydroxide after hydration. MTA Repair HP demonstrated the highest cytocompatibility, and Bio-C Pulpo, the highest cytotoxicity. No inhibition halos were observed for any material, and similar higher turbidity values were seen after direct contact. Composition additives used in Bio-C Pulpo modified its properties, and both the absence of calcium hydroxide deposition after hydration, and the related cytotoxicity of this material are of particular concern. (AU)

FAPESP's process: 17/05096-7 - Evaluation of physical, chemical and antibacterial of a novel high-plasticity repair cement
Grantee:Marina Angélica Marciano da Silva
Support type: Regular Research Grants
FAPESP's process: 17/18413-0 - Evaluation of bioactivity, flowability, pH and calcium release of high-plasticity repair cements
Grantee:Thiago Bessa Marconato Antunes
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/06515-6 - Chemical and structural characterization of high-plasticity reparative cements
Grantee:Gabriela Fernanda Bombarda
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/16722-9 - Diffraction patterns of high-plasticity reparative cements
Grantee:Gabriela Fernanda Bombarda
Support type: Scholarships abroad - Research Internship - Scientific Initiation